Modeling gene-environment interaction in longitudinal data : risk for neuroticism due to interaction between maternal care and the Dopamine 4 Receptor gene (DRD4) Badcock, Paul B., Moore, Elya, Williamson, Elizabeth, Berk, Michael, Williams, Lana J., Bjerkeset, Ottar, Nordahl, Hans M., Patton, George C. and Olsson, Craig A. 2011, Modeling gene-environment interaction in longitudinal data : risk for neuroticism due to interaction between maternal care and the Dopamine 4 Receptor gene (DRD4), Australian journal of psychology, vol. 63, no. 1, pp. 18-25, doi: 10.1111/j.1742-9536.2011.00003.x. Attached Files Name Description MIMEType Size Downloads Title Modeling gene-environment interaction in longitudinal data : risk for neuroticism due to interaction between maternal care and the Dopamine 4 Receptor gene (DRD4) Author(s) Badcock, Paul B. Moore, Elya Williamson, Elizabeth Berk, Michael orcid.org/0000-0002-5554-6946 Williams, Lana J. orcid.org/0000-0002-1377-1272 Bjerkeset, Ottar Nordahl, Hans M. Patton, George C. Olsson, Craig A. orcid.org/0000-0002-5927-2014 Journal name Australian journal of psychology Volume number 63 Issue number 1 Start page 18 End page 25 Total pages 8 Publisher John Wiley & Sons Place of publication Oxford, England Publication date 2011-03 ISSN 0004-9530 1742-9536 Keyword(s) additive interaction DRD4 gene-environment interaction maternal care neuroticism Summary The purpose of this study was to investigate risk for neuroticism due to the joint action of low maternal care and compromised mesocorticolimbic ‘reward’ system function linked to a variable number tandem repeat (VNTR) in the dopamine 4 receptor gene (DRD4). Data were drawn from the Victorian Adolescent Health Cohort Study, a longitudinal study of the health and well-being of 2,000 young Australians followed from adolescence to young adulthood across 8 waves from 14- to 28-years. Genetic risk was defined by carriage of at least one copy of the 7-repeat allele or derivative alleles 5, 6, and 8 (labeled 7R+). Neuroticism was assessed in adolescence and young adulthood. We observed an approximately fourfold increase in the odds of reporting neurotic symptoms in carriers of the 7R+ disposition who reported low maternal care compared with non-carriers who reported high maternal care. The percentage of risk attributable to mechanisms in which both factors played a role was 35%. Findings are discussed in terms of implications for prevention. DOI 10.1111/j.1742-9536.2011.00003.x Field of Research 119999 Medical and Health Sciences not elsewhere classified Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences HERDC Research category C1.1 Refereed article in a scholarly journal Copyright notice ©2011, Wiley-Blackwell Publishing Persistent URL http://hdl.handle.net/10536/DRO/DU:30035790 Document type: Journal Article Collections: School of Psychology School of Medicine Related Links Link Description Connect to published version (restricted access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Wed, 22 Jun 2011, 15:54:05 EST Thu, 06 Oct 2011, 15:00:44 EST Thu, 06 Oct 2011, 15:02:20 EST Tue, 11 Oct 2011, 11:23:36 EST Tue, 10 Jan 2012, 13:22:48 EST Fri, 12 Apr 2013, 14:50:18 EST Mon, 17 Jun 2013, 16:48:38 EST Mon, 16 Jun 2014, 18:28:44 EST Thu, 11 Dec 2014, 17:12:29 EST Filtered Full Citation counts:   Cited 8 times in TR Web of Science Cited 9 times in Scopus Search Google Scholar Access Statistics: 451 Abstract Views, 5 File Downloads  -  Detailed Statistics Created: Wed, 22 Jun 2011, 15:54:05 EST

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