A full body musculoskeletal model based on flexible multibody simulation approach utilised in bone strain analysis during human locomotion

Al Nazer, R., Klodowski, A., Rantalainen, T., Heinonen, A., Sievänen, H. and Mikkola, A. 2011, A full body musculoskeletal model based on flexible multibody simulation approach utilised in bone strain analysis during human locomotion, Computer methods in biomechanics and biomedical engineering, vol. 14, no. 6, pp. 573-579, doi: 10.1080/10255842.2010.488223.

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Title A full body musculoskeletal model based on flexible multibody simulation approach utilised in bone strain analysis during human locomotion
Author(s) Al Nazer, R.
Klodowski, A.
Rantalainen, T.ORCID iD for Rantalainen, T. orcid.org/0000-0001-6977-4782
Heinonen, A.
Sievänen, H.
Mikkola, A.
Journal name Computer methods in biomechanics and biomedical engineering
Volume number 14
Issue number 6
Start page 573
End page 579
Total pages 7
Publisher Taylor & Francis
Place of publication London, England
Publication date 2011-06
ISSN 1025-5842
1476-8259
Keyword(s) bone strains
flexible multibody
simulation
Summary Load-induced strains applied to bone can stimulate its development and adaptation. In order to quantify the incident strains within the skeleton, in vivo implementation of strain gauges on the surfaces of bone is typically used. However, in vivo strain measurements require invasive methodology that is challenging and limited to certain regions of superficial bones only such as the anterior surface of the tibia. Based on our previous study [Al Nazer et al. (2008) J Biomech. 41:1036–1043], an alternative numerical approach to analyse in vivo strains based on the flexible multibody simulation approach was proposed. The purpose of this study was to extend the idea of using the flexible multibody approach in the analysis of bone strains during physical activity through integrating the magnetic resonance imaging (MRI) technique within the framework. In order to investigate the reliability and validity of the proposed approach, a three-dimensional full body musculoskeletal model with a flexible tibia was used as a demonstration example. The model was used in a forward dynamics simulation in order to predict the tibial strains during walking on a level exercise. The flexible tibial model was developed using the actual geometry of human tibia, which was obtained from three-dimensional reconstruction of MRI. Motion capture data obtained from walking at constant velocity were used to drive the model during the inverse dynamics simulation in order to teach the muscles to reproduce the motion in the forward dynamics simulation. Based on the agreement between the literature-based in vivo strain measurements and the simulated strain results, it can be concluded that the flexible multibody approach enables reasonable predictions of bone strain in response to dynamic loading. The information obtained from the present approach can be useful in clinical applications including devising exercises to prevent bone fragility or to accelerate fracture healing.
Notes Available online 06 Feb 2011
Language eng
DOI 10.1080/10255842.2010.488223
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2011, Taylor & Francis
Persistent URL http://hdl.handle.net/10536/DRO/DU:30036186

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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