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An open source approach for regional cortical bone mineral density analysis

Rantalainen, T., Nikander, R., Heinonen, A., Daly, R.M. and Sievänen, H. 2011, An open source approach for regional cortical bone mineral density analysis, Journal of musculoskeletal & neuronal interactions, vol. 11, no. 3, pp. 243-248.

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Title An open source approach for regional cortical bone mineral density analysis
Author(s) Rantalainen, T.
Nikander, R.
Heinonen, A.
Daly, R.M.
Sievänen, H.
Journal name Journal of musculoskeletal & neuronal interactions
Volume number 11
Issue number 3
Start page 243
End page 248
Total pages 6
Publisher International Society of Musculoskeletal and Neuronal Interactions
Place of publication Kifissia, Greece
Publication date 2011-09
ISSN 1108-7161
Keyword(s) pQCT
analysis
image
bone
tibia
Summary Objective: Cortical porosity, particularly at the endocortical region, is recognised to play a central role in the pathogenesis of bone fragility. Therefore, the purpose of this study was to: 1) demonstrate how cortical volumetric BMD (vBMD) distribution can be analysed from (p)QCT images and 2) highlight the clinical significance of assessing regional density distribution of cortical bone. 

Methods: We used pQCT to compare mid-tibial cortical volumetric BMD distribution of 20 young (age 24(SD2) years, mass 77(11) kg, height 178(6) cm) and 25 elderly (72(4) years, 75(9) kg, 172(5) cm) men. Radial and polar cortical vBMD distributions were analysed using a custom built open source analysis tool which allowed the cortex to be divided into three concentric cortical divisions and in 36 cortical sectors originating from the centroid of the bone.

Results:
Mean vBMD did not differ between the groups (1135(16) vs. 1130(28) mg/cm, P=0.696). In contrast, there was a significant age-group by radial division interaction for radial cortical vBMD (P<0.001).

Conclusions:
The proposed analysis method for analysing cortical bone density distribution of pQCT images was effective for detecting regional differences in cortical density between young and elderly men, which would have been missed by just looking at mean vBMD values.
Notes Reproduced with the kind permission of the copyright owner.
Language eng
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970122 Expanding Knowledge in Philosophy and Religious Studies
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2011, International Society of Musculoskeletal and Neuronal Interactions
Persistent URL http://hdl.handle.net/10536/DRO/DU:30036200

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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.