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Patient-reported outcomes following islet cell or pancreas transplantation (alone or after kidney) in type 1 diabetes: a systematic review

Speight, J., Reaney, M.D, Woodcock, A.J., Smith, R.M. and Shaw, J.A.M. 2010, Patient-reported outcomes following islet cell or pancreas transplantation (alone or after kidney) in type 1 diabetes: a systematic review, Diabetic medicine, vol. 27, no. 7, pp. 812-822, doi: 10.1111/j.1464-5491.2010.03029.x.

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Title Patient-reported outcomes following islet cell or pancreas transplantation (alone or after kidney) in type 1 diabetes: a systematic review
Author(s) Speight, J.ORCID iD for Speight, J.
Reaney, M.D
Woodcock, A.J.
Smith, R.M.
Shaw, J.A.M.
Journal name Diabetic medicine
Volume number 27
Issue number 7
Start page 812
End page 822
Total pages 11
Publisher Wiley - Blackwell Publishing
Place of publication Chichester, England
Publication date 2010-07
ISSN 0742-3071
Keyword(s) islet transplantation
pancreas transplantation
patient-reported outcomes
quality of life
Summary Aims For selected individuals with complex Type 1 diabetes, pancreatic islet transplantation (IT) offers the potential of excellent glycaemic controlwithout significant hypoglycaemia, balanced by the need for ongoing systemic immunosuppression. Increasingly, patient-reported outcomes (PROs) are considered alongside biomedical outcomes as a measure of transplant success. PROs in IT have not previously been compared directlywith the closest alternate treatment option, pancreas transplant alone (PTA) or pancreas after kidney (PAK).

Methods We used a Population, Intervention, Comparisons, Outcomes (PICO) strategy to search Scopus and screened 314 references for inclusion.

Results Twelve studies [including PRO assessment of PAK, PTA, islet-after kidney (IAK) and islet transplant alone (ITA); n = 7–205] used a total of nine specified and two unspecified PRO measures. Results were mixed but identified some benefits which remained apparent up to 36 months post-transplant, including improvements in fear of hypoglycaemia, as well as some aspects of diabetes-specific quality of life (QoL) and general health status. Negative outcomes included short-term pain associated with the procedure, immunosuppressant side effects and depressed mood associated with loss of graft function.

Conclusions The mixed resultsmay be attributable to limited sample sizes. Also, some PROmeasures may lack sensitivity to detect actual changes, as they exclude issues and domains of life likely to be important forQoL post-transplantation and when patients may no longer perceive themselves to have diabetes. Thus, the full impact of islet ⁄ pancreas transplantation (alone or after kidney) on QoL is unknown. Furthermore, no studies have assessed patient satisfaction, which may highlight further advantages and disadvantages of transplantation.
Language eng
DOI 10.1111/j.1464-5491.2010.03029.x
Field of Research 170199 Psychology not elsewhere classified
Socio Economic Objective 970117 Expanding Knowledge in Psychology and Cognitive Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2010, Wiley-Blackwell Publishing
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Document type: Journal Article
Collection: School of Psychology
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Citation counts: TR Web of Science Citation Count  Cited 25 times in TR Web of Science
Scopus Citation Count Cited 24 times in Scopus
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Created: Mon, 15 Aug 2011, 14:12:34 EST

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