The suitability of polycystic ovary syndrome-specific questionnaires for measuring the impact of PCOS on quality of life in clinical trials

Malik-Aslam, Aysha, Reaney, Matthew D. and Speight, Jane 2010, The suitability of polycystic ovary syndrome-specific questionnaires for measuring the impact of PCOS on quality of life in clinical trials, Value in health, vol. 13, no. 4, June-July, pp. 440-446.

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Title The suitability of polycystic ovary syndrome-specific questionnaires for measuring the impact of PCOS on quality of life in clinical trials
Author(s) Malik-Aslam, Aysha
Reaney, Matthew D.
Speight, Jane
Journal name Value in health
Volume number 13
Issue number 4
Season June-July
Start page 440
End page 446
Total pages 7
Publisher Wiley - Blackwell Publishing
Place of publication Malden, Mass.
Publication date 2010-06
ISSN 1098-3015
1524-4733
Keyword(s) polycystic ovary syndrome
quality of life
questionnaire
Summary Objectives: Generic patient-reported outcome (PRO) measures underestimate the impact of polycystic ovary syndrome (PCOS) on quality of life (QoL). The aim of this review was to identify PCOS-specific QoL measures and establish whether their development history and measurement properties support their use in clinical trials.

Methods: A systematic search was conducted using terms synonymous with “PCOS” and “QoL.” Following identification of measures, further searches were undertaken using the questionnaire name and abbreviation to explore its use, development history, and demonstrated measurement properties.

Results: Of 56 abstracts screened, 21 reported using PRO measures. One PCOS-specific QoL measure was identified: the PolyCystic Ovary Syndrome Questionnaire (PCOSQ). Nine papers show that the PCOSQ’s development history is somewhat incomplete, and that it does not have good content validity. The PCOSQ subscales demonstrate acceptable levels of reliability (0.70–0.97) and partial known-groups validity as well as convergent/divergent validity with other PRO instruments. Responsiveness
to change is variable and minimally important differences have not been established.

Conclusions: The PCOSQ is the only condition-specific measure of the impact of PCOS on QoL. Additional research is required to ensure its comprehensiveness, sensitivity, and to guide interpretation prior to including in clinical trials.
Language eng
Field of Research 170199 Psychology not elsewhere classified
Socio Economic Objective 970117 Expanding Knowledge in Psychology and Cognitive Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2010, Wiley-Blackwell Publishing
Persistent URL http://hdl.handle.net/10536/DRO/DU:30036453

Document type: Journal Article
Collection: School of Psychology
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