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Frequency of Anti-HBc & HBV DNA detection in blood donors of Kerman province, Iran

Delavari, Maryam, Shahabinejhad, Naser, Renzaho, Andre, Zahedi, Mujawar and Owhadi, AR 2011, Frequency of Anti-HBc & HBV DNA detection in blood donors of Kerman province, Iran, Journal of blood disorders and transfusion, vol. 2, no. 1, pp. 1-4.

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Title Frequency of Anti-HBc & HBV DNA detection in blood donors of Kerman province, Iran
Author(s) Delavari, Maryam
Shahabinejhad, Naser
Renzaho, Andre
Zahedi, Mujawar
Owhadi, AR
Journal name Journal of blood disorders and transfusion
Volume number 2
Issue number 1
Start page 1
End page 4
Publisher OMICS Publishing Group
Place of publication Sunnyvale, Calif.
Publication date 2011-02
ISSN 2155-9864
Keyword(s) occult hepatitis B
hepatitis B virus
blood donor/s
anti-HBc
HBV DNA
Kerman
Iran
Summary Hepatitis B is a serious global infection disease and a major cause of mortality and morbidity worldwide. However, data on Occult Hepatitis B in Iran are scare. The current study assessed the frequency of Anti-HBc and HBV DNA in serum sample of healthy blood donors negative for HBsAg stratified by sex and age; and also investigated the relationship between detection of HBV-DNA and anti-HBc positivity. Since anti-HBc screening is not performed in Iranian Blood Bank, we assessed whether anti-HBc could be adopted as a screening assay for the donated blood. The study included a total of 1525 blood samples of blood donors negative for hepatitis B virus surface antigen ( 87% male with a mean age ± SD: of 31±8yr; and 13% female with a mean age ± SD of 30±6yr). Eight percent (121 out of 1525) of the blood samples with negative HBs-Ag were positive for Anti-HBc and were all from males. HBV-DNA was detected in 36 out of 121 anti-HBc+ specimens (29.7%). The study found a positive relation between anti-HBc positivity and detection of HBV-DNA in serum samples of HBs-Ag negative blood donors. Findings from this study suggest that, introducing anti HBc screening in Iran maybe very practical in order to limit the transmission risk of Occult Hepatitis B virus through blood transfusion.
Notes Reproduced with the kind permission of the copyright owner.
Language eng
Field of Research 111706 Epidemiology
Socio Economic Objective 920109 Infectious Diseases
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2011, OMICS Publishing Group
Persistent URL http://hdl.handle.net/10536/DRO/DU:30036761

Document type: Journal Article
Collections: Population Health
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