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Synthesis, x-ray structure of ferrocene bearing Bis(Zn-cyclen) complexes and the selective electrochemical sensing of TpT

Zeng, Zhanghua, Torriero, Angel A. J., Belousoff, Matthew J., Bond, Alan M. and Spiccia, Leone 2009, Synthesis, x-ray structure of ferrocene bearing Bis(Zn-cyclen) complexes and the selective electrochemical sensing of TpT, Chemistry : a European journal, vol. 15, no. 41, pp. 10988-10996, doi: 10.1002/chem.200901639.

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Title Synthesis, x-ray structure of ferrocene bearing Bis(Zn-cyclen) complexes and the selective electrochemical sensing of TpT
Author(s) Zeng, Zhanghua
Torriero, Angel A. J.ORCID iD for Torriero, Angel A. J. orcid.org/0000-0001-8616-365X
Belousoff, Matthew J.
Bond, Alan M.
Spiccia, Leone
Journal name Chemistry : a European journal
Volume number 15
Issue number 41
Start page 10988
End page 10996
Total pages 9
Publisher Wiley - V C H Verlag GmbH & Co. KGaA
Place of publication Weinheim, Germany
Publication date 2009-10-19
ISSN 0947-6539
1521-3765
Keyword(s) bioinorganic chemistry
ferrocene
macrocycles
sensing
structure elucidation
zinc
Summary The new ligand, [Fc(cyclen)2] (5) (Fc=ferrocene, cyclen=1,4,7,10-tetraazacyclododecane), and corresponding ZnII complex receptor, [Fc{Zn(cyclen)(CH3OH)}2](ClO4)4 (1), consisting of a ferrocene moiety bearing one ZnII-cyclen complex on each cyclopentadienyl ring, have been designed and prepared through a multi-step synthesis. Significant shifts in the 1H NMR signals of the ferrocenyl group, cf. ferrocene and a previously reported [Fc{Zn(cyclen)}]2+ derivative, indicated that the two ZnII-cyclen units in 1 significantly affect the electronic properties of the cyclopentadienyl rings. The X-ray crystal structure shows that the two positively charged ZnII-cyclen complexes are arranged in a trans like configuration, with respect to the ferrocene bridging unit, presumably to minimise electrostatic repulsion. Both 5 and 1 can be oxidized in 1:4 CH2Cl2/CH3CN and Tris-HCl aqueous buffer solution under conditions of cyclic voltammetry to give a well defined ferrocene-centred (Fc0/+) process. Importantly, 1 is a highly selective electrochemical sensor of thymidilyl(3′-5′)thymidine (TpT) relative to other nucleobases and nucleotides in Tris-HCl buffer solution (pH 7.4). The electrochemical selectivity, detected as a shift in reversible potential of the Fc0/+ component, is postulated to result from a change in the configuration of bis(ZnII-cyclen) units from a trans to a cis state. This is caused by the strong 1:1 binding of the two deprotonated thymine groups in TpT to different ZnII centres of receptor 1. UV-visible spectrophotometric titrations confirmed the 1:1 stoichiometry for the 1:TpT adduct and allowed the determination of the apparent formation constant of 0.89±0.10×106 M−1 at pH 7.4.
Language eng
DOI 10.1002/chem.200901639
Field of Research 030604 Electrochemistry
030102 Electroanalytical Chemistry
Socio Economic Objective 970103 Expanding Knowledge in the Chemical Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2009, Wiley-VCH Verlag GmbH&Co. KGaA
Persistent URL http://hdl.handle.net/10536/DRO/DU:30038946

Document type: Journal Article
Collection: Centre for Material and Fibre Innovation
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