Comparative analysis of surface-enhanced Raman spectroscopy of daidzein and formononetin

Sekine, Ryo, Vongsvivut, Jitraporn, Robertson, Evan G., Spiccia, Leone and McNaughton, Don 2010, Comparative analysis of surface-enhanced Raman spectroscopy of daidzein and formononetin, Journal of physical chemistry B, vol. 114, no. 20, pp. 7104-7111, doi: 10.1021/jp101389t.

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Title Comparative analysis of surface-enhanced Raman spectroscopy of daidzein and formononetin
Author(s) Sekine, Ryo
Vongsvivut, Jitraporn
Robertson, Evan G.
Spiccia, Leone
McNaughton, Don
Journal name Journal of physical chemistry B
Volume number 114
Issue number 20
Start page 7104
End page 7111
Total pages 8
Publisher American Chemical Society
Place of publication Washington, D.C.
Publication date 2010-05-27
ISSN 1520-6106
Keyword(s) spectroscopy
Summary Phytoestrogens daidzein (4′,7-dihydroxy-isoflavone) and formononetin (4′-methoxy-7-hydroxy-isoflavone) have been studied by surface-enhanced Raman (SER) spectroscopy. Spectra were acquired in the presence of citratereduced silver colloids, over a range of pH and concentrations. Density functional theory calculations were used to assist assignment of the normal Raman spectra and help determine the mode of interaction of isoflavones with the silver nanoparticles. Formononetin does not show SER activity unless the 7-OH group is deprotonated, and accordingly, the interaction with the silver surface occurs via the deprotonated site. Daidzein, on the other hand, appears to contain multiple species at the surface, interacting via both the hydroxyl groups at 7-OH and 4′-OH, after deprotonation. This is an important result that points to potential future SERS applications in phytoestrogen analysis and provides a foundation for understanding the SER spectra of isoflavones.
Language eng
DOI 10.1021/jp101389t
Field of Research 030101 Analytical Spectrometry
Socio Economic Objective 970103 Expanding Knowledge in the Chemical Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2010, American Chemical Society
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Document type: Journal Article
Collection: School of Life and Environmental Sciences
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