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High torsional energy disulfides : relationship between cross-strand disulfides and right-handed staples

Haworth, Naomi L., Feng, Lina L. and Wouters, Merridee A. 2006, High torsional energy disulfides : relationship between cross-strand disulfides and right-handed staples, Journal of bioinformatics and computational biology, vol. 4, no. 1, pp. 155-168.

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Title High torsional energy disulfides : relationship between cross-strand disulfides and right-handed staples
Author(s) Haworth, Naomi L.
Feng, Lina L.
Wouters, Merridee A.
Journal name Journal of bioinformatics and computational biology
Volume number 4
Issue number 1
Start page 155
End page 168
Publisher Imperial College Press
Place of publication London, England
Publication date 2006
ISSN 1757-6334
0219-7200
Keyword(s) Disulfide
redox signaling
right-handed staple
cross-strand disulfide
Summary Redox-active disulfides are capable of being oxidized and reduced under physiological conditions. The enzymatic role of redox-active disulfides in thiol-disulfide reductases is well-known, but redox-active disulfides are also present in non-enzymatic protein structures where they may act as switches of protein function. Here, we examine disulfides linking adjacent β-strands (cross-strand disulfides), which have been reported to be redox-active. Our previous work has established that these cross-strand disulfides have high torsional energies, a quantity likely to be related to the ease with which the disulfide is reduced. We examine the relationship between conformations of disulfides and their location in protein secondary structures. By identifying the overlap between cross-strand disulfides and various conformations, we wish to address whether the high torsional energy of a cross-strand disulfide is sufficient to confer redox activity or whether other factors, such as the presence of the cross-strand disulfide in a strained β-sheet, are required.
Language eng
Field of Research 060199 Biochemistry and Cell Biology not elsewhere classified
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2006, Imperial College Press
Persistent URL http://hdl.handle.net/10536/DRO/DU:30038978

Document type: Journal Article
Collection: School of Life and Environmental Sciences
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