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High torsional energy disulfides : relationship between cross-strand disulfides and right-handed staples Haworth, Naomi L., Feng, Lina L. and Wouters, Merridee A. 2006, High torsional energy disulfides : relationship between cross-strand disulfides and right-handed staples, Journal of bioinformatics and computational biology, vol. 4, no. 1, pp. 155-168. Attached Files Name Description MIMEType Size Downloads Title High torsional energy disulfides : relationship between cross-strand disulfides and right-handed staples Author(s) Haworth, Naomi L. Feng, Lina L. Wouters, Merridee A. Journal name Journal of bioinformatics and computational biology Volume number 4 Issue number 1 Start page 155 End page 168 Publisher Imperial College Press Place of publication London, England Publication date 2006 ISSN 1757-6334 0219-7200 Keyword(s) Disulfide redox signaling right-handed staple cross-strand disulfide Summary Redox-active disulfides are capable of being oxidized and reduced under physiological conditions. The enzymatic role of redox-active disulfides in thiol-disulfide reductases is well-known, but redox-active disulfides are also present in non-enzymatic protein structures where they may act as switches of protein function. Here, we examine disulfides linking adjacent β-strands (cross-strand disulfides), which have been reported to be redox-active. Our previous work has established that these cross-strand disulfides have high torsional energies, a quantity likely to be related to the ease with which the disulfide is reduced. We examine the relationship between conformations of disulfides and their location in protein secondary structures. By identifying the overlap between cross-strand disulfides and various conformations, we wish to address whether the high torsional energy of a cross-strand disulfide is sufficient to confer redox activity or whether other factors, such as the presence of the cross-strand disulfide in a strained β-sheet, are required. Language eng Field of Research 060199 Biochemistry and Cell Biology not elsewhere classified Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences HERDC Research category C1.1 Refereed article in a scholarly journal Copyright notice ©2006, Imperial College Press Persistent URL http://hdl.handle.net/10536/DRO/DU:30038978 Document type: Journal Article Collection: School of Life and Environmental Sciences Related Links Link Description Connect to published version (restricted access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Mon, 24 Oct 2011, 08:08:23 EST Tue, 25 Oct 2011, 14:03:47 EST Tue, 25 Oct 2011, 14:04:55 EST Thu, 03 Nov 2011, 08:49:03 EST Wed, 13 Nov 2013, 13:21:57 EST Filtered Full Access Statistics: 35 Abstract Views, 1 File Downloads  -  Detailed Statistics Created: Mon, 24 Oct 2011, 08:08:23 EST

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