'Forbidden' disulfides : their role as redox switches Wouters, M. A., George, R. A. and Haworth, N. L. 2007, 'Forbidden' disulfides : their role as redox switches, Current protein and peptide science, vol. 8, no. 5, pp. 484-495. Attached Files Name Description MIMEType Size Downloads Title 'Forbidden' disulfides : their role as redox switches Author(s) Wouters, M. A. George, R. A. Haworth, N. L. Journal name Current protein and peptide science Volume number 8 Issue number 5 Start page 484 End page 495 Total pages 13 Publisher Bentham Science Publishers Place of publication Bussum, The Netherlands Publication date 2007-10 ISSN 1389-2037 1875-5550 Summary Seminal studies by Richardson and Thornton defined the constraints imposed by protein structure on disulfide formation and flagged forbidden regions of primary or secondary structure seemingly incapable of forming disulfide bonds between resident cysteine pairs. With respect to secondary structure, disulfide bonds were not found between cysteine pairs: A. on adjacent beta-stands; B. in a single helix or strand; C. on non-adjacent strands of the same beta-sheet. In primary structure, disulfide bonds were not found between cysteine pairs: D. adjacent in the sequence. In the intervening years it has become apparent that all these forbidden regions are indeed occupied by disulfide-bonded cysteines, albeit rather strained ones. It has been observed that sources of strain in a protein structure, such as residues in forbidden regions of the Ramachandran plot and cis-peptide bonds, are found in functionally important regions of the protein and warrant further investigation. Like the Ramachandran plot, the earlier studies by Richardson and Thornton have identified a fundamental truth in protein stereochemistry: "forbidden" disulfides adopt strained conformations, but there is likely a functional reason for this. Emerging evidence supports a role for forbidden disulfides in redox-regulation of proteins. Language eng Field of Research 060199 Biochemistry and Cell Biology not elsewhere classified Socio Economic Objective 970105 Expanding Knowledge in the Environmental Sciences HERDC Research category C1.1 Refereed article in a scholarly journal Copyright notice ©2007, Bentham Science Publishers Persistent URL http://hdl.handle.net/10536/DRO/DU:30038991 Document type: Journal Article Collections: Faculty of Science, Engineering and Built Environment School of Life and Environmental Sciences Related Links Link Description Connect to published version (restricted access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Mon, 24 Oct 2011, 08:08:56 EST Fri, 28 Oct 2011, 11:25:37 EST Fri, 28 Oct 2011, 11:26:51 EST Thu, 03 Nov 2011, 08:51:58 EST Mon, 20 Aug 2012, 12:51:51 EST Wed, 12 Jun 2013, 12:31:45 EST Wed, 03 Jul 2013, 09:34:33 EST Wed, 13 Nov 2013, 13:33:32 EST Filtered Full Citation counts:   Cited 46 times in TR Web of Science Cited 45 times in Scopus Search Google Scholar Access Statistics: 155 Abstract Views, 2 File Downloads  -  Detailed Statistics Created: Mon, 24 Oct 2011, 08:08:56 EST

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