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Fabrication and biofunctionalization of selenium-polypyrrole core-shell nanoparticles for targeting and imaging of cancer cells

Li, Jing-Liang and Liu, Xiang-Yang 2008, Fabrication and biofunctionalization of selenium-polypyrrole core-shell nanoparticles for targeting and imaging of cancer cells, Journal of nanoscience and nanotechnology, vol. 8, no. 5, pp. 2488-2491, doi: 10.1166/jnn.2008.502.

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Title Fabrication and biofunctionalization of selenium-polypyrrole core-shell nanoparticles for targeting and imaging of cancer cells
Author(s) Li, Jing-LiangORCID iD for Li, Jing-Liang orcid.org/0000-0003-0709-2246
Liu, Xiang-Yang
Journal name Journal of nanoscience and nanotechnology
Volume number 8
Issue number 5
Start page 2488
End page 2491
Total pages 4
Publisher American Scientific
Place of publication Valencia, Calif.
Publication date 2008-05
ISSN 1533-4880
1533-4899
Summary Selenium-polypyrrole core-shell nanoparticles are fabricated by an in-situ polymerization process and functionalized with transferrin for targeting and imaging of human cervical cancer cells. The shell thickness and chemical composition of the as-synthesized particles can be manipulated by controlling the precursor concentration. The presence of the polymer layer can greatly increase the thermal stability of the selenium nanoparticles. The presence of transferrin molecules on the surface of the core-shell nanoparticles can significantly enhance their cellular uptake. The tranferrin-conjugated core-shell nanoparticles can be potentially used for the targeting and imaging of cancer cells.
Language eng
DOI 10.1166/jnn.2008.502
Field of Research 100708 Nanomaterials
100703 Nanobiotechnology
020599 Optical Physics not elsewhere classified
Socio Economic Objective 970110 Expanding Knowledge in Technology
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2008, American Scientific
Persistent URL http://hdl.handle.net/10536/DRO/DU:30039299

Document type: Journal Article
Collection: Centre for Material and Fibre Innovation
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