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Cancer-cell microsurgery using nonlinear optical endomicroscopy

Gu, Min, Bao, Hong Chun and Li, Jing Liang 2010, Cancer-cell microsurgery using nonlinear optical endomicroscopy, Journal of biomedical optics, vol. 15, no. 5, pp. 1-3, doi: 10.1117/1.3502566.

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Title Cancer-cell microsurgery using nonlinear optical endomicroscopy
Author(s) Gu, Min
Bao, Hong Chun
Li, Jing LiangORCID iD for Li, Jing Liang orcid.org/0000-0003-0709-2246
Journal name Journal of biomedical optics
Volume number 15
Issue number 5
Start page 1
End page 3
Total pages 3
Publisher International Society for Optical Engineering
Place of publication Bellingham, Wash.
Publication date 2010-09
ISSN 1083-3668
Summary Near-infrared laser-based microsurgery is promising for noninvasive cancer treatment. To make it a safe technique, a therapeutic process should be controllable and energy efficient, which requires the cancer cells to be identifiable and observable. In this work, for the first time we use a miniaturized nonlinear optical endomicroscope to achieve microtreatment of cancer cells labeled with gold nanorods. Due to the high two-photon-excited photoluminescence of gold nanorods, HeLa cells inside a tissue phantom up to 250 μm deep can be imaged by the nonlinear optical endomicroscope. This facilitates microsurgery of selected cancer cells by inducing instant damage through the necrosis process, or by stopping cell proliferation through the apoptosis process. The results indicate that a combination of nonlinear endomicroscopy with gold nanoparticles is potentially viable for minimally invasive cancer treatment.
Language eng
DOI 10.1117/1.3502566
Field of Research 100708 Nanomaterials
100703 Nanobiotechnology
020599 Optical Physics not elsewhere classified
Socio Economic Objective 970110 Expanding Knowledge in Technology
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2010, SPIE
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30039324

Document type: Journal Article
Collections: Centre for Material and Fibre Innovation
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.