You are not logged in.
Openly accessible

A role for SSU72 in balancing RNA polymerase II transcription elongation and termination

Dichtl, Bernhard, Blank, Diana, Ohnacker, Martin, Friedlein, Arno, Roeder, Daniel, Langen, Hanno and Keller, Walter 2002, A role for SSU72 in balancing RNA polymerase II transcription elongation and termination, Molecular cell, vol. 10, no. 5, pp. 1139-1150, doi: 10.1016/S1097-2765(02)00707-4.

Attached Files
Name Description MIMEType Size Downloads
dichtl-roleforssu72-2002.pdf Published version application/pdf 644.94KB 75

Title A role for SSU72 in balancing RNA polymerase II transcription elongation and termination
Author(s) Dichtl, BernhardORCID iD for Dichtl, Bernhard orcid.org/0000-0001-5514-4982
Blank, Diana
Ohnacker, Martin
Friedlein, Arno
Roeder, Daniel
Langen, Hanno
Keller, Walter
Journal name Molecular cell
Volume number 10
Issue number 5
Start page 1139
End page 1150
Total pages 12
Publisher Cell Press
Place of publication Cambridge, Mass.
Publication date 2002-11-01
ISSN 1097-2765
1097-4164
Keyword(s) azauracil
RNA polymerase II
transcription factor
Summary Interactions of pre-mRNA 3′end factors and the CTD of RNA polymerase II (RNAP II) are required for transcription termination and 3′end processing. Here, we demonstrate that Ssu72p is stably associated with yeast cleavage and polyadenylation factor CPF and provide evidence that it bridges the CPF subunits Pta1p and Ydh1p/Cft2p, the general transcription factor TFIIB, and RNAP II via Rpb2p. Analyses of ssu72-2 mutant cells in the absence and presence of the nuclear exosome component Rrp6p revealed defects in RNAP II transcription elongation and termination. 6-azauracil, that reduces transcription elongation rates, suppressed the ssu72-2 growth defect at 33°C. The sum of our analyses suggests a negative influence of Ssu72p on RNAP II during transcription that affects the commitment to either elongation or termination.
Language eng
DOI 10.1016/S1097-2765(02)00707-4
Field of Research 060199 Biochemistry and Cell Biology not elsewhere classified
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2002, Elsevier
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30039332

Document type: Journal Article
Collections: School of Life and Environmental Sciences
Open Access Collection
Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 109 times in TR Web of Science
Scopus Citation Count Cited 110 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 183 Abstract Views, 75 File Downloads  -  Detailed Statistics
Created: Mon, 24 Oct 2011, 14:18:52 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.