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Immunologic significance of respirable atmospheric starch granules containing major birch allergen Bet v 1 Schappi, G. F., Taylor, P. E., Staff, I. A., Rolland, J. M. and Suphioglu, C 1999, Immunologic significance of respirable atmospheric starch granules containing major birch allergen Bet v 1, Allergy, vol. 54, no. 5, pp. 478-483. Attached Files Name Description MIMEType Size Downloads Title Immunologic significance of respirable atmospheric starch granules containing major birch allergen Bet v 1 Author(s) Schappi, G. F. Taylor, P. E. Staff, I. A. Rolland, J. M. Suphioglu, C Journal name Allergy Volume number 54 Issue number 5 Start page 478 End page 483 Total pages 6 Publisher Wiley-Blackwell Place of publication West Sussex, England Publication date 1999 ISSN 0105-4538 Keyword(s) allergens starch granules respirable fine particles micronic particles birch pollen Bet v 1 allergic asthma Summary Background: Birch-pollen allergens are an important cause of early spring hay fever and allergic asthma. Recently, we reported a mechanism for the release of respirable allergenic particles from birch pollen containing the major allergen Bet v 1. In this study, we aimed to assess the immunologic significance of the released Bet v 1-containing starch granules in the environment. Methods: A two-site monoclonal antibody-based assay (ELISA) was employed to quantitate Bet v 1 in high-volume air sampler filter extracts, and immunogold-labelling was used on sections of these extracts to localize Bet v 1. Immunoblot analyses were performed with pooled sera from patients sensitive to birch pollen. Results: Atmospheric starch granules contained Bet v 1, and the concentration increased upon light rainfall. Sera from patients allergic to birch allergens recognized extracts from isolated starch granules. Conclusions: The clinical implications of these findings are that starch granules released from birch pollen are potentially able to trigger allergic asthmatic reactions to Bet v 1, since the allergen occurs in respirable particles. Thus, clinicians can advise asthma patients to remain indoors on days of light rainfall during the birch-pollen season to avoid high levels of allergen exposure. Language eng Field of Research 060199 Biochemistry and Cell Biology not elsewhere classified Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences HERDC Research category C1.1 Refereed article in a scholarly journal Persistent URL http://hdl.handle.net/10536/DRO/DU:30039878 Document type: Journal Article Collection: School of Life and Environmental Sciences Related Links Link Description Connect to published version (restricted access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Wed, 02 Nov 2011, 08:41:55 EST Thu, 09 May 2013, 13:34:05 EST Thu, 09 May 2013, 13:35:43 EST Filtered Full Citation counts:   Cited 35 times in TR Web of Science Cited 38 times in Scopus Search Google Scholar Access Statistics: 30 Abstract Views, 0 File Downloads  -  Detailed Statistics Created: Wed, 02 Nov 2011, 08:41:55 EST

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