A general approach to N-heterocyclic scaffolds using domino Heck-aza-Michael reactions

Priebbenow, Daniel L., Stewart, Scott G. and Pfeffer, Frederick M. 2011, A general approach to N-heterocyclic scaffolds using domino Heck-aza-Michael reactions, Organic and biomolecular chemistry, vol. 9, no. 5, pp. 1508-1515.

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Title A general approach to N-heterocyclic scaffolds using domino Heck-aza-Michael reactions
Author(s) Priebbenow, Daniel L.
Stewart, Scott G.
Pfeffer, Frederick M.
Journal name Organic and biomolecular chemistry
Volume number 9
Issue number 5
Start page 1508
End page 1515
Total pages 8
Publisher Royal Society of Chemistry
Place of publication Cambridge, U. K.
Publication date 2011
ISSN 1477-0520
1477-0539
Summary Palladium-catalyzed domino Heck–aza-Michael reactions for the synthesis of a series of C1-substituted tetrahydro-β-carbolines, tetrahydroisoquinolines and isoindolines are described. The domino process involves the initial intermolecular Heck reaction of an aryl bromide with an electron deficient alkene, followed by an intramolecular aza-Michael reaction to form the new N-heterocycle in high yield.
Language eng
Field of Research 030503 Organic Chemical Synthesis
Socio Economic Objective 970103 Expanding Knowledge in the Chemical Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2011, The Royal Society of Chemistry
Persistent URL http://hdl.handle.net/10536/DRO/DU:30040415

Document type: Journal Article
Collection: School of Life and Environmental Sciences
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