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A one-pot, three-component approach to functionalised tetrahydroisoquinolines using domino Heck-aza-Michael reactions

Priebbenow, Daniel L., Pfeffer, Frederick M. and Stewart, Scott G. 2011, A one-pot, three-component approach to functionalised tetrahydroisoquinolines using domino Heck-aza-Michael reactions, European journal of organic chemistry, vol. 2011, no. 9, pp. 1632-1635.

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Title A one-pot, three-component approach to functionalised tetrahydroisoquinolines using domino Heck-aza-Michael reactions
Author(s) Priebbenow, Daniel L.
Pfeffer, Frederick M.
Stewart, Scott G.
Journal name European journal of organic chemistry
Volume number 2011
Issue number 9
Start page 1632
End page 1635
Total pages 4
Publisher Wiley - V C H Verlag GmbH & Co. KGaA
Place of publication Weinheim, Germany
Publication date 2011-03
ISSN 1434-193X
1099-0690
Keyword(s) tetrahydroisoquinoline
multicomponent reactions
domino reactions
heck reaction
Aza-Michael addition
palladium
Summary A one-pot, three-component method incorporating a domino Heck–aza-Michael reaction has been developed for the rapid synthesis of functionalised tetrahydroisoquinolines. Following the in situ generation of an acrylamide, a domino process involving intermolecular Heck reaction and subsequent intramolecular aza-Michael addition affords tetrahydroisoquinolines bearing C1-acetamide functionality.
Language eng
Field of Research 030503 Organic Chemical Synthesis
Socio Economic Objective 970103 Expanding Knowledge in the Chemical Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2011, Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
Persistent URL http://hdl.handle.net/10536/DRO/DU:30040417

Document type: Journal Article
Collection: School of Life and Environmental Sciences
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