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Suppressor of cytokine signaling 1 regulates embryonic myelopoiesis independently of its effects on T cell development

O'Sullivan, Lynda A., Noor, Suzita M., Trengove, Monique C., Lewis, Rowena S., Liongue, Clifford, Sprigg, Naomi S., Nicholson, Sandra E. and Ward, Alister C. 2011, Suppressor of cytokine signaling 1 regulates embryonic myelopoiesis independently of its effects on T cell development, Journal of immunology, vol. 186, no. 8, pp. 4751-4761, doi: 10.4049/jimmunol.1000343.

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Title Suppressor of cytokine signaling 1 regulates embryonic myelopoiesis independently of its effects on T cell development
Author(s) O'Sullivan, Lynda A.
Noor, Suzita M.
Trengove, Monique C.
Lewis, Rowena S.
Liongue, CliffordORCID iD for Liongue, Clifford
Sprigg, Naomi S.
Nicholson, Sandra E.
Ward, Alister C.ORCID iD for Ward, Alister C.
Journal name Journal of immunology
Volume number 186
Issue number 8
Start page 4751
End page 4761
Total pages 11
Publisher American Association of Immunologists
Place of publication Bethesda, Md.
Publication date 2011-04-15
ISSN 0022-1767
Summary Suppressor of cytokine signaling 1 (SOCS1) has been shown to play important roles in the immune system. It acts as a key negative regulator of signaling via receptors for IFNs and other cytokines controlling T cell development, as well as Toll receptor signaling in macrophages and other immune cells. To gain further insight into SOCS1, we have identified and characterized the zebrafish socs1 gene, which exhibited sequence and functional conservation with its mammalian counterparts. Initially maternally derived, the socs1 gene showed early zygotic expression in mesodermal structures, including the posterior intermediate cell mass, a site of primitive hematopoiesis. At later time points, expression was seen in a broad anterior domain, liver, notochord, and intersegmental vesicles. Morpholino-mediated knockdown of socs1 resulted in perturbation of specific hematopoietic populations prior to the commencement of lymphopoiesis, ruling out T cell involvement. However, socs1 knockdown also lead to a reduction in the size of the developing thymus later in embryogenesis. Zebrafish SOCS1 was shown to be able to interact with both zebrafish Jak2a and Stat5.1 in vitro and in vivo. These studies demonstrate a conserved role for SOCS1 in T cell development and suggest a novel T cell-independent function in embryonic myelopoiesis mediated, at least in part, via its effects on receptors using the Jak2-Stat5 pathway.
Language eng
DOI 10.4049/jimmunol.1000343
Field of Research 069999 Biological Sciences not elsewhere classified
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2011, The American Association of Immunologists
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Document type: Journal Article
Collections: School of Medicine
School of Life and Environmental Sciences
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Created: Mon, 05 Dec 2011, 12:42:39 EST

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