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Alzheimer's, angiotensin IV and an aminopeptidase

Albiston, Anthony Lloyd, Fernando, Ruani, Ye, Siying, Peck, Grantley Ross and Chai, Siew Yeen 2004, Alzheimer's, angiotensin IV and an aminopeptidase, Biological and pharmaceutical bulletin, vol. 27, no. 6, pp. 765-767, doi: 10.1248/bpb.27.765.

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Title Alzheimer's, angiotensin IV and an aminopeptidase
Author(s) Albiston, Anthony Lloyd
Fernando, Ruani
Ye, Siying
Peck, Grantley Ross
Chai, Siew Yeen
Journal name Biological and pharmaceutical bulletin
Volume number 27
Issue number 6
Start page 765
End page 767
Total pages 3
Publisher Pharmaceutical Society of Japan
Place of publication Tokyo, Japan
Publication date 2004-06
ISSN 0918-6158
1347-5215
Keyword(s) Ang IV
LVV-hemorphin-7
insulin-regulated aminopeptidase (IRAP)
Summary The angiotensin AT4 receptor was originally defined as the specific, high affinity binding site for the hexapeptide angiotensin IV (Ang IV). Subsequently, the peptide LVV-hemorphin 7 was also demonstrated to be a bioactive ligand of the AT4 receptor. Central administration of Ang IV or LVV-hemorphin 7 (LVV-H7) markedly enhances learning and memory in normal rodents and reverse memory deficits observed in animal models of amnesia. The high affinity binding site has a broad distribution in the brain including areas such as the hippocmapus that are involved in memory processing. The high affinity Ang IV binding site (AT4 receptor) has been identified as the transmembrane enzyme, insulin-regulated membrane aminopeptidase (IRAP). Insulin-regulated aminopeptidase is a type II integral membrane spanning protein belonging to the M1 family of aminopeptidases and in insulin-responsive cells colocalizes with GLUT4 in specific intra-cellular vesicles. Both Ang IV and LVV-H7 are competitive inhibitors of IRAP catalytic activity and are not substrates of the enzyme.
Language eng
DOI 10.1248/bpb.27.765
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C2.1 Other contribution to refereed journal
Copyright notice ©2004, Pharmaceutical Society of Japan
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30040944

Document type: Journal Article
Collections: School of Medicine
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.