The fur seal — a model lactation phenotype to explore molecular factors involved in the initiation of apoptosis at involution

Sharp, Julie A., Lefevre, Christophe, Brennan, Amelia J. and Nicholas, Kevin R. 2007, The fur seal — a model lactation phenotype to explore molecular factors involved in the initiation of apoptosis at involution, Journal of mammary gland biology and neoplasia, vol. 12, no. 1, pp. 47-58.

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Title The fur seal — a model lactation phenotype to explore molecular factors involved in the initiation of apoptosis at involution
Author(s) Sharp, Julie A.
Lefevre, Christophe
Brennan, Amelia J.
Nicholas, Kevin R.
Journal name Journal of mammary gland biology and neoplasia
Volume number 12
Issue number 1
Start page 47
End page 58
Total pages 12
Publisher Springer New York LLC
Place of publication New York, N.Y.
Publication date 2007-03
ISSN 1083-3021
Keyword(s) Fur seal
Lactation
Local control
Mammary gland
Involution
Acute phase response
Summary Mammary gland involution requires co-ordination of milk production, immune responses, apoptosis and remodeling. Initiation and progression of each of these components involves integral control by the mammary gland. Although cell-based culture models and genetically manipulated animals have shed light on these processes, the factors controlling each step in the involution cascade are still poorly understood. The fur seal displays a unique lactation phenotype. During the lactation cycle the mammary gland downregulates milk production and initiates an immune response but fails to initiate the apoptotic phase of involution, allowing the female fur seal to undertake long foraging trips of up to 28 days between suckling bouts. Upon return to shore the female continues feeding her pup following resumption of lactation and milk production. Expression profiling of genes involved in this lactation cycle provides valuable tools for investigation of the factors responsible for the initiation of apoptosis at involution.
Language eng
Field of Research 060405 Gene Expression (incl Microarray and other genome-wide approaches)
060305 Evolution of Developmental Systems
060103 Cell Development, Proliferation and Death
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
HERDC collection year 2007
Copyright notice ©2007, Springer
Persistent URL http://hdl.handle.net/10536/DRO/DU:30040974

Document type: Journal Article
Collection: Centre for Biotechnology and Interdisciplinary Sciences (BioDeakin)
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Created: Wed, 07 Dec 2011, 13:01:38 EST by Julie Sharp

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