Functional analysis of proteins involved in Plasmodium falciparum merozoite invasion of red blood cells

Cowman, Alan F., Baldi, Deborah L., Healer, Julie, Mills, Kerry E., O'Donnell, Rebecca A., Reed, Michael B., Triglia, Tony, Wickham, Mark E. and Crabb, Brendan S. 2000, Functional analysis of proteins involved in Plasmodium falciparum merozoite invasion of red blood cells, FEBS letters, vol. 476, no. 1-2, pp. 84-88.

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Title Functional analysis of proteins involved in Plasmodium falciparum merozoite invasion of red blood cells
Formatted title Functional analysis of proteins involved in Plasmodium falciparum merozoite invasion of red blood cells
Author(s) Cowman, Alan F.
Baldi, Deborah L.
Healer, Julie
Mills, Kerry E.
O'Donnell, Rebecca A.
Reed, Michael B.
Triglia, Tony
Wickham, Mark E.
Crabb, Brendan S.
Journal name FEBS letters
Volume number 476
Issue number 1-2
Start page 84
End page 88
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2000-06-30
ISSN 0014-5793
1873-3468
Keyword(s) malaria
vaccine antigen
targeted gene disruption
plasmodium falciparum
Summary Plasmodium falciparum causes the most lethal form of malaria in humans and is responsible for over two million deaths per year. The development of a vaccine against this parasite is an urgent priority and potential protein targets include those on the surface of the asexual merozoite stage, the form that invades the host erythrocyte. The development of methods to transfect P. falciparum has enabled the construction of gain-of-function and loss-of-function mutants and provided new strategies to analyse the role of parasite proteins. In this review, we describe the use of this technology to examine the role of merozoite antigens in erythrocyte invasion and to address their potential as vaccine candidates.
Language eng
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2000, Federation of European Biochemical Societies
Persistent URL http://hdl.handle.net/10536/DRO/DU:30041064

Document type: Journal Article
Collection: School of Medicine
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