Three dimensional scaffolds from multilobal fibres for enhanced cell growth
Wong, Cynthia, Nuhiji, Edin, Sutti, Alessandra, Keating, Graeme, Liu, Xin, Kirkland, Mark and Wang, Xungai 2011, Three dimensional scaffolds from multilobal fibres for enhanced cell growth, in ATC 2011 : Proceedings of the Asian Textile Conference : Knowledge Convergence in Textiles for Human and Nature, Korean Fiber Society, [Daegu, Korea], pp. 27-30.
Multilobal fibres are irregularly shaped fibres with several surface channels or grooves. Scaffolds created from these fibres have high surface area which may enhance cell density. This study compared the cell growth of dermal fibroblasts and osteoblast-like SaOS2 cells on multilobal fibre nonwoven scaffolds to the conventional fibre scaffolds. Cells were cultured on round nylon, trilobal nylon, round polyethylene terephthalate (PET) and multilobal PET scaffolds for 14 days. There were more cells growing on trilobal nylon and PET multilobal scaffolds than their round counterparts. The preference to the type of multilobal scaffolds was cell dependent. The density of fibroblast increased 37% on trilobal nylon compared to round nylon scaffolds after 14 days of culture. SaOS2 cells preferred the multilobal PET scaffolds, exhibiting a 66% increase in cell number after 14 days of culture. Scaffolds manufactured from multilobal fibres have the ability to accommodate a high number of cells, demonstrating a great potential in tissue engineering applications.
Field of Research
Socio Economic Objective
970109 Expanding Knowledge in Engineering
HERDC Research category
E2 Full written paper - non-refereed / Abstract reviewed