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Drug release rate and anti-microbial effect of controlled-diffusion biopolymer membranes

Liu, Xin, Lin, Tong, Huang, Chen, Xu, Zhiguang and Wang, Xungai 2011, Drug release rate and anti-microbial effect of controlled-diffusion biopolymer membranes, in NANO 2011 : International Conference on Nanoscience and Technology : Book of abstracts, [National Center for Nanoscience and Technology, China], [Beijing, China], pp. 85-85.

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Title Drug release rate and anti-microbial effect of controlled-diffusion biopolymer membranes
Author(s) Liu, Xin
Lin, Tong
Huang, Chen
Xu, Zhiguang
Wang, Xungai
Conference name International Conference on Nanoscience and Technology (2011 : Beijing, China)
Conference location Beijing, China
Conference dates 7-9 Sep. 2011
Title of proceedings NANO 2011 : International Conference on Nanoscience and Technology : Book of abstracts
Editor(s) [Unknown]
Publication date 2011
Conference series International Conference on Nanoscience and Technology
Start page 85
End page 85
Total pages 1
Publisher [National Center for Nanoscience and Technology, China]
Place of publication [Beijing, China]
Keyword(s) drug release
electrospun membrane
anit-microbial
biopolymer
Summary In this study, a series of fibrous membranes made from cellulose acetate (CA) and polyester urethane (PEU) by co-electrospining or blend-electrospining were evaluated for drug release kinetics, in vitro anti-microbial activity and in vivo would healing performance when used as wound dressings. To stop common clinical infections, an antibacterial agent, Polyhexamethylene Biguanide (PHMB) was incorporated into e-spun fibres. The presence of CA in the wound healing membrane was found to improve hydrophilicity and permeability to air and moisture. The in vivo tests indicated that the addition of PHMB and CA considerably improved the wound healing efficiency. CA fibres became slightly swollen upon contacting with the wound exudates. It can not only speed up the liquid evaporation but also create a moisture environment for wound recovery. The drug release dynamics of membranes was controlled by the structure of membranes and component rations within membranes. The lower ration of CA:PEU retained the sound mechanical properties of membranes, and also reduced the boost release effectively and slowed down diffusion of antibacterial agent during in vitro tests. The controlled-diffusion membranes exert long-term anti-infective effect.
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Language eng
Field of Research 100708 Nanomaterials
Socio Economic Objective 920299 Health and Support Services not elsewhere classified
HERDC Research category E3 Extract of paper
Copyright notice ©2011, NCNTC
Persistent URL http://hdl.handle.net/10536/DRO/DU:30042296

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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.