Design of a high sensitive double-gate field-effect transistor biosensor for DNA detection

Islam, Md. Saiful and Kouzani, Abbas Z. 2011, Design of a high sensitive double-gate field-effect transistor biosensor for DNA detection, in EMBC 2011 : Proceedings of the 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, IEEE, [Boston, Mass.], pp. 4788-4791.

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Title Design of a high sensitive double-gate field-effect transistor biosensor for DNA detection
Author(s) Islam, Md. Saiful
Kouzani, Abbas Z.
Conference name IEEE Engineering in Medicine and Biology Society. Conference (33rd : 2011 : Boston, Mass.)
Conference location Boston, Mass.
Conference dates 30 Aug.-3 Sep. 2011
Title of proceedings EMBC 2011 : Proceedings of the 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Editor(s) [Unknown]
Publication date 2011
Conference series IEEE Engineering in Medicine and Biology Society. Conference
Start page 4788
End page 4791
Total pages 4
Publisher IEEE
Place of publication [Boston, Mass.]
Keyword(s) biosensors
DNA
FETs
logic gates
nanobioscience
sensitivity
signal to noise ratio
Summary The study of interactions between organic biomolecules and semiconducting surfaces is an important consideration for the design and fabrication of field-effect-transistor (FET) biosensor. This paper demonstrates DNA detection by employing a double-gate field effect transistor (DGFET). In addition, an investigation of sensitivity and signal to noise ratio (SNR) is carried out for different values of analyte concentration, buffer ion concentration, pH, reaction constant, etc. Sensitivity, which is indicated by the change of drain current, increases non-linearly after a specific value (∼1nM) of analyte concentration and decreases non-linearly with buffer ion concentration. However, sensitivity is linearly related to the fluidic gate voltage. The drain current has a significant effect on the positive surface group (-NH2) compared to the negative counterpart (-OH). Furthermore, the sensor has the same response at a particular value of pH (5.76) irrespective of the density of surface group, although it decreases with pH value. The signal to noise ratio is improved with higher analyte concentrations and receptor densities.
ISBN 1424441218
9781424441211
ISSN 1557-170X
Language eng
Field of Research 099999 Engineering not elsewhere classified
Socio Economic Objective 970109 Expanding Knowledge in Engineering
HERDC Research category E1 Full written paper - refereed
Copyright notice ©2011, IEEE
Persistent URL http://hdl.handle.net/10536/DRO/DU:30042372

Document type: Conference Paper
Collection: School of Engineering
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