Elevated levels of triglyceride and triglyceride-rich lipoprotein triglyceride induced by a high-carbohydrate diet is associated with polymorphisms of AP0A5-1131T>C and AP0C3-482C> in chinese healthy young adults

Lin, Jia, Fang, Ding Zhi, Du, Juan, Shigdar, Sarah, Xiao, Li Ying, Zhou, Xue Dong and Duan, Wei 2011, Elevated levels of triglyceride and triglyceride-rich lipoprotein triglyceride induced by a high-carbohydrate diet is associated with polymorphisms of AP0A5-1131T>C and AP0C3-482C> in chinese healthy young adults, Annals of nutrition and metabolism, vol. 58, no. 2, pp. 150-157.


Title Elevated levels of triglyceride and triglyceride-rich lipoprotein triglyceride induced by a high-carbohydrate diet is associated with polymorphisms of AP0A5-1131T>C and AP0C3-482C> in chinese healthy young adults
Author(s) Lin, Jia
Fang, Ding Zhi
Du, Juan
Shigdar, Sarah
Xiao, Li Ying
Zhou, Xue Dong
Duan, Wei
Journal name Annals of nutrition and metabolism
Volume number 58
Issue number 2
Start page 150
End page 157
Publisher S. Karger AG
Place of publication Basel, Switzerland
Publication date 2011-06
ISSN 1421-9697
0250-6807
Keyword(s) apolipoproteins A5 C3
high-carbohydrate/low-fat diet
polymorphisms
serum lipids
Summary Background/aims: Changes in lipid profiles have been shown to be associated with diet and apolipoprotein (APO) polymorphisms. Therefore, 2 polymorphisms, i.e. APOA5-1131T>C and APOC3-482C>T, and serum lipids were examined in a Chinese healthy young population with high-carbohydrate/low-fat (HC/LF) diet intervention.

Methods: After a wash-out diet for 7 days, 56 young adults (22.89 +/- 1.80 years) received the HC/LF diet for 6 days. Body mass index (BMI) and fasting serum lipid profiles at baseline, after the wash-out diet, and after the HC/LF diet were measured.

Results: APOA5-1131C carriers had higher triglyceride (TG) and TG-rich lipoprotein TG (TRL-TG) levels at baseline and after the HC/LF diet, though this mainly corresponded to the female cohort. APOC3-482T carriers had higher TRL-TG levels following the wash-out and HC/LF diets, but these were not directly attributable to a single gender.

Conclusions: Both polymorphisms may play an important role in the elevated TG and TRL-TG levels induced by the HC/LF diet, especially in females, thus indicating a potential dietary prevention of coronary heart disease in this Chinese cohort.
Language eng
Field of Research 111102 Dietetics and Nutrigenomics
Socio Economic Objective 920411 Nutrition
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2011, S. Karger AG
Persistent URL http://hdl.handle.net/10536/DRO/DU:30042587

Document type: Journal Article
Collection: School of Medicine
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