Associations of the SREBP-1c gene polymorphism with gender-specific changes in serum lipids induced by a high-carbohydrate diet in healthy Chinese youth

Zhang, Zhen, Gong, Ren Rong, Du, Juan, Xiao, Li Ying, Duan, Wei, Zhou, Xue Dong and Fang, Ding Zhi 2011, Associations of the SREBP-1c gene polymorphism with gender-specific changes in serum lipids induced by a high-carbohydrate diet in healthy Chinese youth, Applied physiology, nutrition and metabolism, vol. 36, no. 2, pp. 226-232.

Attached Files
Name Description MIMEType Size Downloads

Title Associations of the SREBP-1c gene polymorphism with gender-specific changes in serum lipids induced by a high-carbohydrate diet in healthy Chinese youth
Author(s) Zhang, Zhen
Gong, Ren Rong
Du, Juan
Xiao, Li Ying
Duan, Wei
Zhou, Xue Dong
Fang, Ding Zhi
Journal name Applied physiology, nutrition and metabolism
Volume number 36
Issue number 2
Start page 226
End page 232
Publisher N R C Research Press
Place of publication Ottawa, Canada
Publication date 2011-04
ISSN 1715-5312
1715-5320
Keyword(s) sterol regulatory element-binding protein-1c
personalized nutrition
hypertriacylglycerolemia
coronary heart disease
Summary We investigated the possible association between the sterol regulatory element-binding protein-1c gene (SREBP-1c) rs2297508 polymorphism and the changes in lipid profiles in a high-carbohydrate and low-fat (high-CHO/LF) diet in a Chinese population well characterized by a lower incidence of coronary heart disease and a diet featuring higher carbohydrate and lower fat. Fifty-six healthy youth (aged 22.89 ± 1.80 years) were given wash-out diets of 31% fat and 54% carbohydrate for 7 days, followed by the high-CHO/LF diet of 15% fat and 70% carbohydrate for 6 days, without total energy restriction. Fasting blood samples were collected. Serum variables of lipid and glucose metabolism after the wash-out and high-CHO/LF diets, as well as the rs2297508 polymorphism, were analyzed. Compared with the male subjects on the wash-out diet, significantly elevated levels of high-density lipoprotein cholesterol (HDL-C) and decreased levels of apolipoprotein B-100 were observed in the male carriers of the C allele after the high-CHO/LF diet. In the female subjects, significantly increased triacylglycerol levels, insulin, and homeostasis model assessment of insulin resistance (HOMA-IR) were found in the GG genotype after the high-CHO/LF diet. These results suggest that the C allele of the rs2297508 polymorphism is associated with a retardation of the increases in serum triacylglycerol, serum insulin, and HOMA-IR in females and with the elevated serum HDL-C in males after the high-CHO/LF diet.
Language eng
Field of Research 111102 Dietetics and Nutrigenomics
Socio Economic Objective 920411 Nutrition
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Persistent URL http://hdl.handle.net/10536/DRO/DU:30042588

Document type: Journal Article
Collections: School of Medicine
Open Access Checking
Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 1 times in TR Web of Science
Scopus Citation Count Cited 1 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 52 Abstract Views, 2 File Downloads  -  Detailed Statistics
Created: Wed, 22 Feb 2012, 11:03:51 EST by Jane Moschetti

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.