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Clinical applications of aptamers and nucleic acid therapeutics in haematological malignancies

Shigdar, Sarah, Ward, Alister C., De, Abhijit, Yang, Chaoyong J., Wei, Mingqian and Duan, Wei 2011, Clinical applications of aptamers and nucleic acid therapeutics in haematological malignancies, British journal of haematology, vol. 155, no. 1, pp. 3-13.

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Title Clinical applications of aptamers and nucleic acid therapeutics in haematological malignancies
Author(s) Shigdar, Sarah
Ward, Alister C.
De, Abhijit
Yang, Chaoyong J.
Wei, Mingqian
Duan, Wei
Journal name British journal of haematology
Volume number 155
Issue number 1
Start page 3
End page 13
Total pages 11
Publisher Wiley - Blackwell Publishing
Place of publication Oxford, U. K.
Publication date 2011-10
ISSN 0007-1048
1365-2141
Keyword(s) aptamers
nucleic acid-based therapeutics
oligonucleotides
RNAi
targeted therapeutics
Summary Haematological malignancies result from a heterogeneous mix of genetic mutations and chromosome aberrations and translocations. Targeted therapies, such as the anti-CD20 antibody rituximab, or the BCR-ABL1 inhibitor imatinib, have proven to be effective treatments in the management of some of these malignancies, though relapsing or refractory disease is still common. Nucleic acid-based therapies have also entered the clinical arena, providing an alternative, complementary approach. The forerunner of these therapies were the antisense oligonucleotides, but their scope has expanded to include short-interfering RNA (siRNA), microRNA, decoy oligonucleotides and aptamers. These can be used either as monotherapeutics, in conjunction with current chemotherapy regimens, or in combination with each other to improve therapeutic efficacy. Not only can these nucleic acid-based therapies silence target genes, they also have the potential of restoring gene function. While challenges remain in delivering effective doses of nucleic acid in vivo, these are steadily being met, suggesting an optimistic future in the treatment of haematological malignancies. This review summarizes the application of nucleic acid-based therapeutics, particularly aptamers, in the diagnosis and treatment of haematological malignancies.
Notes Article first published online 2nd August 2011
Language eng
Field of Research 111204 Cancer Therapy (excl Chemotherapy and Radiation Therapy)
Socio Economic Objective 920101 Blood Disorders
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2011, Blackwell Publishing Ltd.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30042589

Document type: Journal Article
Collection: School of Medicine
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