Effects of lipoprotein lipase gene variations, a high-carbohydrate low-fat diet, and gender on serum lipid profiles in healthy Chinese Han youth

Huang, Xin, Gong, Renrong, Lin, Jia, Li, Ronghui, Xiao, Liying, Duan, Wei and Fang, Dingzhi 2011, Effects of lipoprotein lipase gene variations, a high-carbohydrate low-fat diet, and gender on serum lipid profiles in healthy Chinese Han youth, Bioscience trends, vol. 5, no. 5, pp. 198-204.

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Title Effects of lipoprotein lipase gene variations, a high-carbohydrate low-fat diet, and gender on serum lipid profiles in healthy Chinese Han youth
Author(s) Huang, Xin
Gong, Renrong
Lin, Jia
Li, Ronghui
Xiao, Liying
Duan, Wei
Fang, Dingzhi
Journal name Bioscience trends
Volume number 5
Issue number 5
Start page 198
End page 204
Total pages 7
Publisher International Advancement Centre for Medicine & Health Research Co., Ltd
Place of publication Tokyo, Japan
Publication date 2011
ISSN 1881-7815
1881-7823
Keyword(s) high-carbohydrate low-fat diet
lipoprotein lipase
SNP
serum lipids
glucose
insulin resistance
Summary A high-carbohydrate low-fat (HC/LF) diet and lipoprotein lipase gene (LPL) Ser447Stop and Hind III polymorphisms have separately been found to be associated with triacylglycerol (TG) and high density lipoprotein cholesterol (HDL-C). This study sought to test the effects of LPL polymorphisms and an HC/LF diet on the serum lipid profile of Chinese with a lower incidence of coronary artery disease (CAD) consuming a diet with less fat and more carbohydrates. Fifty-six healthy subjects (22.89 ± 1.80 years) were given a control diet of 30.1% fat and 54.1% carbohydrates for 7 days, followed by an HC/LF diet of 13.8% fat and 70.1% carbohydrate for 6 days; there were no changes in the fatty acid composition or restrictions on total energy. Serum lipid profiles at baseline, before and after the HC/LF diet, and LPL polymorphisms were analyzed. After 6 days of the HC/LF diet, TG and the homeostasis model assessment of insulin resistance (HOMAIR) index were found to increase only in females with S447S. No decrease in HDL-C was noted. In subjects with Hind III polymorphism, increased TG was found in all females but not in males. Increased HDL-C, together with apolipoprotein (apo) AI, was found in male H- carriers but not in males with H+/H+ and females. In conclusion, LPL Ser447Stop and Hind III polymorphisms modified the effects of an HC/LF diet on the serum lipid profiles of a young Chinese population in different ways. Effective strategies for dietary interventions targeted at younger populations should take into account the interplay between genetic polymorphisms, diet, and gender.
Language eng
Field of Research 111102 Dietetics and Nutrigenomics
Socio Economic Objective 920411 Nutrition
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Persistent URL http://hdl.handle.net/10536/DRO/DU:30042591

Document type: Journal Article
Collection: School of Medicine
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