Endogenous parathyroid hormone is associated with reduced cartilage volume in vivo in a population-based sample of adult women

Brennan, Sharon Lee, Cicuttini, Flavia M., Nicholson, Geoff C., Pasco, Julie A., Kotowicz, Mark A. and Wluka, Anita E. 2012, Endogenous parathyroid hormone is associated with reduced cartilage volume in vivo in a population-based sample of adult women, Annals of the rheumatic diseases, vol. 71, no. 6, pp. 1000-1003.

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Title Endogenous parathyroid hormone is associated with reduced cartilage volume in vivo in a population-based sample of adult women
Author(s) Brennan, Sharon Lee
Cicuttini, Flavia M.
Nicholson, Geoff C.
Pasco, Julie A.
Kotowicz, Mark A.
Wluka, Anita E.
Journal name Annals of the rheumatic diseases
Volume number 71
Issue number 6
Start page 1000
End page 1003
Total pages 4
Publisher BMJ Group
Place of publication London, U. K.
Publication date 2012-06
ISSN 0003-4967
1468-2060
Keyword(s) animal studies
in vitro studies
parathyroid hormone (PTH)
osteoarthritis
cartilage
Geelong
Summary Objectives Animal and in vitro studies suggest that parathyroid hormone (PTH) may affect articular cartilage. However, little is known of the relationship between PTH and human joints in vivo.

Design Longitudinal.

Setting Barwon Statistical Division, Victoria, Australia.

Participants 101 asymptomatic women aged 35–49 years (2007–2009) and without clinical knee osteoarthritis, selected from the population-based Geelong Osteoporosis Study.

Risk factors Blood samples obtained 10 years before (1994–1997) and stored at −80°C for random batch analyses. Serum intact PTH was quantified by chemiluminescent enzyme assay. Serum 25-hydroxyvitamin D (25(OH)D) was assayed using equilibrium radioimmunoassay. Models were adjusted for age, bone area and body mass index; further adjustment was made for 25(OH)D and calcium supplementation.

Outcome Knee cartilage volume, measured by MRI.

Results A higher lnPTH was associated with reduced medial—but not lateral—cartilage volume (regression coefficient±SD, p value: −72.2±33.6 mm3, p=0.03) after adjustment for age, body mass index and bone area. Further sinusoidal adjustment (−80.8±34.4 mm3, p=0.02) and 25(OH)D with seasonal adjustment (−72.7±35.1 mm3, p=0.04), calcium supplementation and prevalent osteophytes did not affect the results.

Conclusions A higher lnPTH might be detrimental to knee cartilage in vivo. Animal studies suggest that higher PTH concentrations reduce the healing ability of cartilage following minor injury. This may be apparent in the presence of increased loading, which occurs in the medial compartment, placing the medial cartilage at higher risk for injury.
Language eng
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2012, BMJ Publishing
Persistent URL http://hdl.handle.net/10536/DRO/DU:30042758

Document type: Journal Article
Collection: School of Medicine
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