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Femoral neck geometry and hip fracture risk : the Geelong Osteoporosis Study

El-Kaissi, S., Pasco, J. A., Henry, M. J., Panahi, S., Nicholson, J. G., Nicholson, G. C. and Kotowicz, M. A. 2005, Femoral neck geometry and hip fracture risk : the Geelong Osteoporosis Study, Osteoporosis International, vol. 16, no. 10, pp. 1299-1303, doi: 10.1007/s00198-005-1988-z.

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Title Femoral neck geometry and hip fracture risk : the Geelong Osteoporosis Study
Author(s) El-Kaissi, S.
Pasco, J. A.ORCID iD for Pasco, J. A.
Henry, M. J.
Panahi, S.
Nicholson, J. G.
Nicholson, G. C.
Kotowicz, M. A.ORCID iD for Kotowicz, M. A.
Journal name Osteoporosis International
Volume number 16
Issue number 10
Start page 1299
End page 1303
Total pages 5
Publisher Springer U. K.
Place of publication Surrey, England
Publication date 2005
ISSN 0937-941X
Keyword(s) bone mineral density
femoral neck geometry
hip axis length
hip fracture
Summary To determine the relationship between femoral neck geometry and the risk of hip fracture in post-menopausal Caucasian women, we conducted a retrospective study comparing the femoral neck dimensions of 62 hip fracture cases to those of 608 randomly selected controls. Measurements were made from dual-energy X-ray absorptiometry scans (Lunar DPX-L), using the manufacturers ruler function, and included: hip axis length (HAL), femoral neck axis length (FNAL), femoral neck width (FNW), femoral shaft width (FSW), medial femoral shaft cortical thickness (FSCTmed), and lateral femoral shaft cortical thickness (FSCTlat). The fracture group was older (median age 78.3 years vs 73.8 years), lighter (median weight 59.9 kg vs 64.5 kg), and, after adjustment for age, taller (mean height 158.7±0.8 cm vs 156.7±0.2 cm) than the controls. Furthermore, bone mineral density was lower in this group (0.682±0.016 g/cm2 vs 0.791±0.006 g/cm2). After adjustment for age, bone mineral content (BMC) or height, hip fracture patients had greater FNW (up to 6.6%) and FSW (up to 6.3%) than did the controls. Each standard deviation increase in FNW and FSW was associated with a 1.7-fold (95% CI 1.3–2.3) and a 2.4-fold (95% CI 1.8–3.2) increase in the fracture risk, respectively. BMC-adjusted FNAL was greater in the fracture group (+2.1%) than in the controls, while the age-adjusted FSCTmed was reduced (–7.2%). There was a trend towards longer HAL (up to 2.1%) after adjustment for age or BMC, and thinner age-adjusted FSCTlat (–1.7%) in fracture patients that did not reach statistical significance. In multivariate analysis, the risk of hip fracture was predicted by the combination of age, FNW, FSW, BMC and FSCTmed. HAL was not analyzed because of the small number of HAL measurements among fracture cases. We conclude that post-menopausal women with hip fractures have wider femoral necks and shafts, thinner femoral cortices and longer femoral neck axis lengths than do women with no fractures. Alteration in hip geometry is associated with the risk of hip fracture.
Language eng
DOI 10.1007/s00198-005-1988-z
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2005, International Osteoporosis Foundation and National Osteoporosis Foundation
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Document type: Journal Article
Collection: School of Medicine
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