Fracture risk (FRISK) score : Geelong Osteoporosis Study

Henry, Margaret Joy, Pasco, Julie Anne, Sanders, Kerrie Margaret, Nicholson, Geoffrey Charles and Kotowicz, Mark Anthony 2006, Fracture risk (FRISK) score : Geelong Osteoporosis Study, Radiology, vol. 241, no. 1, pp. 190-196.

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Title Fracture risk (FRISK) score : Geelong Osteoporosis Study
Author(s) Henry, Margaret Joy
Pasco, Julie Anne
Sanders, Kerrie Margaret
Nicholson, Geoffrey Charles
Kotowicz, Mark Anthony
Journal name Radiology
Volume number 241
Issue number 1
Start page 190
End page 196
Total pages 7
Publisher Radiological Society of North America
Place of publication Oak Brook, Ill.
Publication date 2006-10
ISSN 0033-8419
1527-1315
Keyword(s) fracture risk score
FRISK
Summary Purpose: To develop and evaluate a fracture risk (FRISK) score based on multiple-site bone mineral density (BMD) measurements and other risk factors, to enable prediction of future fracture occurrence.

Materials and Methods:
All participants gave written informed consent, and the study was approved by the Barwon Health Research and Ethics Advisory Committee. BMD was measured at the femoral neck and spine in two concurrently recruited groups: women 60 years of age or older who had sustained a low-trauma fracture of the hip, spine, humerus or distal forearm during a 2-year ascertainment period (n = 231; mean age, 74 years ± 7 [standard deviation]) and a population-based random sample of women who had not sustained a fracture during the recruitment period (n = 448; mean age, 72 years ± 8). Falls in the previous year and the number of self-reported fractures in adult life were recorded. Coefficients of a multiple logistic regression model were used as weightings for a combined model. A longitudinal population-based sample was used to assess the fracture risk equation (n = 600; median age, 74 years; interquartile range, 67–82 years).

Results:
The FRISK score was obtained from the following equation: 9.304 − 4.735BMDSP − 4.530BMDFN + 1.127FS + 0.344NPF + 0.037W, where BMDSP is spinal BMD (in grams per square centimeter), BMDFN is femoral neck BMD, FS is falls score, NPF is number of previous fractures, and W is weight (in kilograms). The FRISK score successfully predicted 75% of fractures 2 years after baseline measurements in subjects in the longitudinal study with 68% specificity.

Conclusion:
This study resulted in the derivation of a fracture risk score that successfully predicted 75% of fractures 2 years after baseline.
Language eng
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2006, Radiological Society of North America
Persistent URL http://hdl.handle.net/10536/DRO/DU:30042781

Document type: Journal Article
Collection: School of Medicine
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