Assessment of fracture risk : value of random population-based samples - the Geelong Osteoporosis Study

Henry, Margaret J., Pasco, Julie A., Seeman, Ego, Nicholson, Geoffrey C., Sanders, Kerrie M. and Kotowicz, Mark A. 2001, Assessment of fracture risk : value of random population-based samples - the Geelong Osteoporosis Study, Journal of clinical densitometry, vol. 4, no. 4, Winter, pp. 283-289.


Title Assessment of fracture risk : value of random population-based samples - the Geelong Osteoporosis Study
Author(s) Henry, Margaret J.
Pasco, Julie A.
Seeman, Ego
Nicholson, Geoffrey C.
Sanders, Kerrie M.
Kotowicz, Mark A.
Journal name Journal of clinical densitometry
Volume number 4
Issue number 4
Season Winter
Start page 283
End page 289
Total pages 8
Publisher Elsevier B.V.
Place of publication Amsterdam, The Netherlands
Publication date 2001
ISSN 1094-6950
1559-0747
Keyword(s) bone mineral density
population based
reference range
sampling
volunteers
Summary Fracture risk is determined by bone mineral density (BMD). The T-score, a measure of fracture risk, is the position of an individual's BMD in relation to a reference range. The aim of this study was to determine the magnitude of change in the T-score when different sampling techniques were used to produce the reference range. Reference ranges were derived from three samples, drawn from the same region: (1) an age-stratified population-based random sample, (2) unselected volunteers, and (3) a selected healthy subset of the population-based sample with no diseases or drugs known to affect bone. T-scores were calculated using the three reference ranges for a cohort of women who had sustained a fracture and as a group had a low mean BMD (ages 35-72 yr; n = 484). For most comparisons, the T-scores for the fracture cohort were more negative using the population reference range. The difference in T-scores reached 1.0 SD. The proportion of the fracture cohort classified as having osteoporosis at the spine was 26, 14, and 23% when the population, volunteer, and healthy reference ranges were applied, respectively. The use of inappropriate reference ranges results in substantial changes to T-scores and may lead to inappropriate management.
Language eng
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2001, Elsevier B.V.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30042783

Document type: Journal Article
Collection: School of Medicine
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