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Fracture thresholds revisited : Geelong Osteoporosis Study

Henry, M. J., Pasco, J. A., Seeman, E., Nicholson, G. C., Sanders, K. M. and Kotowicz, M. A. 2002, Fracture thresholds revisited : Geelong Osteoporosis Study, Journal of clinical epidemiology, vol. 55, no. 7, pp. 642-646.

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Title Fracture thresholds revisited : Geelong Osteoporosis Study
Author(s) Henry, M. J.
Pasco, J. A.
Seeman, E.
Nicholson, G. C.
Sanders, K. M.
Kotowicz, M. A.
Journal name Journal of clinical epidemiology
Volume number 55
Issue number 7
Start page 642
End page 646
Total pages 5
Publisher Elsevier
Place of publication New York, N.Y.
Publication date 2002-07
ISSN 0895-4356
Keyword(s) fracture thresholds
bone mineral density
fracture prediction
Summary Osteoporosis, in the absence of fracture, is defined as a deficit in bone mineral density (BMD) of 2.5 SD or more below the young adult reference mean in postmenopausal Caucasian populations. BMD is a measure of fracture risk but not the sole predictor. We have assessed a combination of easily accessible measures of age, height, weight, and BMD to improve fracture risk assessment. Women with low trauma fractures and a control group were recruited from south-eastern Australia. Discriminant analysis derived multivariate equations that assessed fracture risk. Age was not in the best models at the spine and forearm sites. Weight and height contributed to the relationship for the forearm sites only. At the proximal femur, the BMD level that separates fracture cases from nonfracture cases, increases with age. These separation levels of BMD were higher than the WHO's level of osteoporosis (T-score < −2.5 SD) at ages older than 62 years. This increasing BMD threshold with age suggests that other age-related risk factors assume increasing importance among the elderly.
Language eng
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2002, Elsevier Science
Persistent URL http://hdl.handle.net/10536/DRO/DU:30042784

Document type: Journal Article
Collection: School of Medicine
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