Maternal 25-hydroxyvitamin D concentration and offspring birth size : effect modification by infant VDR genotype

Morley, R., Carlin, J. B., Pasco, J. A., Wark, J. D. and Ponsonby, A. L. 2009, Maternal 25-hydroxyvitamin D concentration and offspring birth size : effect modification by infant VDR genotype, European journal of clinical nutrition, vol. 63, no. 6, pp. 802-804.

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Title Maternal 25-hydroxyvitamin D concentration and offspring birth size : effect modification by infant VDR genotype
Author(s) Morley, R.
Carlin, J. B.
Pasco, J. A.
Wark, J. D.
Ponsonby, A. L.
Journal name European journal of clinical nutrition
Volume number 63
Issue number 6
Start page 802
End page 804
Total pages 3
Publisher Nature Publishing Group
Place of publication London, England
Publication date 2009-06
ISSN 0954-3007
Keyword(s) VDR
vitamin D
pregnancy
birth weight
Summary Background/Objectives: We tested the hypothesis that the relationship between maternal 25-hydroxyvitamin D (25-(OH)D) and offspring birth size differs according to offspring vitamin D receptor (VDR) genotype (Apa1, Bsm1, Fok1 or Taq1).

Subjects/Methods: Mothers of 354 singleton babies had serum 25-(OH)D concentration measured at 28–30 weeks of gestation and consented to measurement of their babies soon after birth. DNA was extracted from the babies’ Guthrie cards.

Results: There was evidence of effect modification by infant FokI genotype. Babies of deficient mothers had lower birth weight with FF or Ff, but not ff genotype (P-value for interaction after adjustment for potential confounding factors=0.02), but thicker subscapular and suprailiac skinfolds with ff, but not FF or Ff genotype (P=0.008 and 0.02, respectively). Sample size was insufficient to investigate effect modification by the other VDR polymorphisms.

Conclusions:
These preliminary findings suggest that studies of maternal vitamin D status and birth size may need to take VDR genotype into account.
Language eng
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2009, Macmillan Publishers
Persistent URL http://hdl.handle.net/10536/DRO/DU:30042788

Document type: Journal Article
Collection: School of Medicine
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