Serum leptin levels are associated with bone mass in nonobese women

Pasco, Julie A., Henry, Margaret J., Kotowicz, Mark A., Collier, Gregory R., Ball, Madeleine J., Ugoni, Antony M. and Nicholson, Geoffrey C. 2001, Serum leptin levels are associated with bone mass in nonobese women, Journal of clinical endorinology and metabolism, vol. 86, no. 5, pp. 1884-1887, doi: 10.1210/jc.86.5.1884.

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Title Serum leptin levels are associated with bone mass in nonobese women
Author(s) Pasco, Julie A.ORCID iD for Pasco, Julie A.
Henry, Margaret J.
Kotowicz, Mark A.ORCID iD for Kotowicz, Mark A.
Collier, Gregory R.
Ball, Madeleine J.
Ugoni, Antony M.
Nicholson, Geoffrey C.
Journal name Journal of clinical endorinology and metabolism
Volume number 86
Issue number 5
Start page 1884
End page 1887
Total pages 4
Publisher J. B. Lippincott
Place of publication Philadelphia, PA
Publication date 2001-05
ISSN 0021-972X
Keyword(s) Aged, 80 and over
Body Weight
Bone Density
Summary Both serum leptin and bone mineral density are positively correlated with body fat, generating the hypothesis that leptin may be a systemic and/or local regulator of bone mass. We investigated 214 healthy, nonobese Australian women aged 20-91 yr. Bone mineral content, projected bone area, and body fat mass were measured by dual energy x-ray absorptiometry and fasting serum leptin levels by RIA. Associations between bone mineral content (adjusted for age, body weight, body fat mass, and bone area) and the natural logarithm of serum leptin concentrations were analyzed by multiple regression techniques. There was a significant positive association at the lateral spine, two proximal femur sites (Ward's triangle and trochanter), and whole body (partial r2 = 0.019 to 0.036; all P < 0.05). Similar trends were observed at the femoral neck and posterior-anterior-spine. With bone mineral density the dependent variable (adjusted for age, body weight, and body fat mass), the association with the natural logarithm of leptin remained significant at the lateral spine (partial r2 = 0.030; P = 0.011), was of borderline significance at the proximal femur sites (partial r2 = 0.012 to 0.017; P = 0.058 to 0.120), and was not significant at the other sites. Our results demonstrate an association between serum leptin levels and bone mass consistent with the hypothesis that circulating leptin may play a role in regulating bone mass.
Language eng
DOI 10.1210/jc.86.5.1884
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2001, The Endocrine Society
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Document type: Journal Article
Collection: School of Medicine
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