Statin use, bone mineral density, and fracture risk: Geelong Osteoporosis Study

Pasco, Julie A., Kotowicz, Mark A., Henry, Margaret J., Sanders, Kerrie M. and Nicholson, Geoffrey C. 2002, Statin use, bone mineral density, and fracture risk: Geelong Osteoporosis Study, Archives of internal medicine, vol. 162, no. 5, pp. 537-540.

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Title Statin use, bone mineral density, and fracture risk: Geelong Osteoporosis Study
Author(s) Pasco, Julie A.ORCID iD for Pasco, Julie A.
Kotowicz, Mark A.ORCID iD for Kotowicz, Mark A.
Henry, Margaret J.
Sanders, Kerrie M.
Nicholson, Geoffrey C.
Journal name Archives of internal medicine
Volume number 162
Issue number 5
Start page 537
End page 540
Total pages 4
Publisher American Medical Association
Place of publication Chicago, Ill.
Publication date 2002-03-11
ISSN 0003-9926
Keyword(s) statin use
bone mineral density
fracture risk
Geelong Osteoporosis Study
Summary Background Recent data suggest that 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) decrease fracture risk and increase bone mineral density (BMD).

Methods This cross-sectional study is set in southeastern Australia. We evaluated the association between statin use, fracture risk, and BMD in 1375 women (573 with incident fractures and 802 without incident fracture, all drawn from the same community). Fractures were identified radiologically. Medication use and lifestyle factors were documented by questionnaire.

Results Unadjusted odds ratio for fracture associated with statin use was 0.40 (95% confidence interval [CI], 0.23-0.71). Adjusting for BMD at the femoral neck, spine, and whole body increased the odds ratio to 0.45 (95% CI, 0.25-0.80), 0.42 (95% CI, 0.24-0.75), and 0.43 (95% CI, 0.24-0.78), respectively. Adjusting for age, weight, concurrent medications, and lifestyle factors had no substantial effect on the odds ratio for fracture. Statin use was associated with a 3% greater adjusted BMD at the femoral neck (P = .08), and BMD tended to be greater at the spine and whole body but did not achieve statistical significance.

Conclusion The substantial 60% reduction in fracture risk associated with statin use is greater than would be expected from increases in BMD alone.
Language eng
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2002, American Medical Association
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