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Health outcomes associated with hormone therapy in Australian women

Pasco, Julie A., Kotowicz, Mark A., Henry, Margaret J., Sanders, Kerrie M. and Nicholson, Geoffrey C. 2009, Health outcomes associated with hormone therapy in Australian women, Current drug safety, vol. 4, no. 3, pp. 169-172.

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Title Health outcomes associated with hormone therapy in Australian women
Author(s) Pasco, Julie A.ORCID iD for Pasco, Julie A.
Kotowicz, Mark A.ORCID iD for Kotowicz, Mark A.
Henry, Margaret J.
Sanders, Kerrie M.
Nicholson, Geoffrey C.
Journal name Current drug safety
Volume number 4
Issue number 3
Start page 169
End page 172
Total pages 4
Publisher Bentham Science Publishers
Place of publication San Francisco, Calif.
Publication date 2009-09
ISSN 1574-8863
Keyword(s) hormone therapy
health outcomes
Australian women
Summary The risks and benefits of hormone therapy (HT) in the treatment of postmenopausal women remain controversial. In this population-based, observational study, we documented health outcomes among postmenopausal Australian women using HT. Women aged 60-80 years were recruited into the Geelong Osteoporosis Study 1994-7 and followed over a median period of 6.6 years. Mortality, and the development of vascular events, breast and colorectal cancers were documented for 67 HT-users and 521 non-users. Median duration of HT-use was 5.0 years (IQR 3.0-10.0). There was no excess in all-cause mortality associated with HT-use. Based on 92 deaths (six HT-users, 86 non-users), the adjusted odds ratio (OR) for all-cause mortality was 0.79 (95%CI 0.32-1.97). With 99 reports of vascular events (13 HTusers, 86 non-users), the adjusted OR for vascular events was 1.30 (95%CI 0.66-2.57). There were insufficient numbers of breast or colorectal cancer cases (21 breast cancer cases, all non-HT users; and 7 colorectal cancer cases, one HT-user and six non-users) to adequately calculate the risk associated with exposure to HT. Although the sample size was small, these results do not support an association between HT and mortality, despite a possible link between HT and increased risk of developing vascular disease.
Language eng
Field of Research 110399 Clinical Sciences not elsewhere classified
Socio Economic Objective 920199 Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2009, Bentham Science Publishers
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Document type: Journal Article
Collection: School of Medicine
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