Hormone therapy and risk of non-vertebral fracture : Geelong Osteoporosis Study

Pasco, Julie A., Kotowicz, Mark A., Henry, Margaret J., Sanders, Kerrie M., Seeman, Ego and Nicholson, Geoffrey C. 2004, Hormone therapy and risk of non-vertebral fracture : Geelong Osteoporosis Study, Osteoporosis International, vol. 15, no. 6, pp. 434-438, doi: 10.1007/s00198-003-1574-1.

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Title Hormone therapy and risk of non-vertebral fracture : Geelong Osteoporosis Study
Author(s) Pasco, Julie A.ORCID iD for Pasco, Julie A. orcid.org/0000-0002-8968-4714
Kotowicz, Mark A.ORCID iD for Kotowicz, Mark A. orcid.org/0000-0002-8094-1411
Henry, Margaret J.
Sanders, Kerrie M.
Seeman, Ego
Nicholson, Geoffrey C.
Journal name Osteoporosis International
Volume number 15
Issue number 6
Start page 434
End page 438
Total pages 5
Publisher Springer U. K.
Place of publication Surrey, England
Publication date 2004
ISSN 0937-941X
Keyword(s) bone mineral density
hormone therapy
population-based study
postmenopausal women
Summary In this population-based study, we evaluated the association between exposure to hormone therapy (HT), bone mineral density (BMD) and the prevalence of non-vertebral fractures. The study was set in a region located in southeastern Australia where complete fracture ascertainment was determined from radiological reports. Current HT use for at least 6 months was ascertained in women with non-vertebral fractures [median age 70.9 years; inter-quartile range (IQR) 66.5–75.9 years] and randomly selected controls (median age 70.8 years; IQR 65.2–75.0 years). Current HT use was documented in 20 of 262 cases and 49 of 364 controls. The odds ratio (OR) for non-vertebral fracture associated with HT use was 0.53 (95% CI 0.31–0.92). HT use was associated with 2.6–7.5% higher BMD at axial and appendicular sites. HT use is associated with a halving of risk for non-vertebral fractures and higher BMD.
Language eng
DOI 10.1007/s00198-003-1574-1
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2004, International Osteoporosis Foundation and National Osteoporosis Foundation
Persistent URL http://hdl.handle.net/10536/DRO/DU:30042817

Document type: Journal Article
Collection: School of Medicine
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