You are not logged in.

Origins of adaptive immunity

Liongue, Clifford, John, Liza and Ward, Alister 2011, Origins of adaptive immunity, Critical reviews in immunology, vol. 31, no. 1, pp. 61-71.

Attached Files
Name Description MIMEType Size Downloads

Title Origins of adaptive immunity
Author(s) Liongue, CliffordORCID iD for Liongue, Clifford
John, Liza
Ward, AlisterORCID iD for Ward, Alister
Journal name Critical reviews in immunology
Volume number 31
Issue number 1
Start page 61
End page 71
Total pages 11
Publisher Begell House Inc.
Place of publication Redding, Conn.
Publication date 2011
ISSN 1040-8401
Keyword(s) adaptive immunity
cytokine signaling
transcription factors
Summary Adaptive immunity, involving distinctive antibody- and cell-mediated responses to specific antigens based on "memory" of previous exposure, is a hallmark of higher vertebrates. It has been argued that adaptive immunity arose rapidly, as articulated in the "big bang theory" surrounding its origins, which stresses the importance of coincident whole-genome duplications. Through a close examination of the key molecules and molecular processes underpinning adaptive immunity, this review suggests a less-extreme model, in which adaptive immunity emerged as part of longer evolutionary journey. Clearly, whole-genome duplications provided additional raw genetic materials that were vital to the emergence of adaptive immunity, but a variety of other genetic events were also required to generate some of the key molecules, whereas others were preexisting and simply co-opted into adaptive immunity.
Language eng
Field of Research 110704 Cellular Immunology
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
HERDC collection year 2011
Persistent URL

Document type: Journal Article
Collection: School of Medicine
Connect to link resolver
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 4 times in TR Web of Science
Scopus Citation Count Cited 8 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 397 Abstract Views, 2 File Downloads  -  Detailed Statistics
Created: Fri, 02 Mar 2012, 13:30:30 EST by Penny Andrews

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact