Origins of adaptive immunity

Liongue, Clifford, John, Liza and Ward, Alister 2011, Origins of adaptive immunity, Critical reviews in immunology, vol. 31, no. 1, pp. 61-71.

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Title Origins of adaptive immunity
Author(s) Liongue, Clifford
John, Liza
Ward, Alister
Journal name Critical reviews in immunology
Volume number 31
Issue number 1
Start page 61
End page 71
Total pages 11
Publisher Begell House Inc.
Place of publication Redding, Conn.
Publication date 2011
ISSN 1040-8401
2162-6472
Keyword(s) adaptive immunity
evolution
BCR
TCR
MHC
RAG
cytokine signaling
transcription factors
Summary Adaptive immunity, involving distinctive antibody- and cell-mediated responses to specific antigens based on "memory" of previous exposure, is a hallmark of higher vertebrates. It has been argued that adaptive immunity arose rapidly, as articulated in the "big bang theory" surrounding its origins, which stresses the importance of coincident whole-genome duplications. Through a close examination of the key molecules and molecular processes underpinning adaptive immunity, this review suggests a less-extreme model, in which adaptive immunity emerged as part of longer evolutionary journey. Clearly, whole-genome duplications provided additional raw genetic materials that were vital to the emergence of adaptive immunity, but a variety of other genetic events were also required to generate some of the key molecules, whereas others were preexisting and simply co-opted into adaptive immunity.
Language eng
Field of Research 110704 Cellular Immunology
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
HERDC collection year 2011
Persistent URL http://hdl.handle.net/10536/DRO/DU:30042859

Document type: Journal Article
Collection: School of Medicine
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