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Differential effects of dietary canola and soybean oil intake on oxidative stress in stroke-prone spontaneously hypertensive rats Papazzo, Annateresa, Conlan, Xavier A., Lexis, Louise and Lewandowski, Paul A. 2011, Differential effects of dietary canola and soybean oil intake on oxidative stress in stroke-prone spontaneously hypertensive rats, Lipids in health and diease, vol. 10, no. 98, pp. 1-8. Attached Files Name Description MIMEType Size Downloads conlan-differentialeffects-2011.pdf Published version application/pdf 343.11KB 19 Title Differential effects of dietary canola and soybean oil intake on oxidative stress in stroke-prone spontaneously hypertensive rats Author(s) Papazzo, Annateresa Conlan, Xavier A. Lexis, Louise Lewandowski, Paul A. Journal name Lipids in health and diease Volume number 10 Issue number 98 Start page 1 End page 8 Publisher BioMed Central Place of publication London, England Publication date 2011 ISSN 1476-511X Keyword(s) soybean oil canola oxidative stress Summary Background: Canola oil shortens the life span of stroke-prone spontaneously hypertensive (SHRSP) rats compared with rats fed soybean oil when given as the sole dietary lipid source. One possible mechanism leading to the damage and deterioration of organs due to canola oil ingestion is oxidative stress. This study investigated the effect of canola oil intake on oxidative stress in this animal model. Method: Male SHRSP rats, were fed a defatted control diet containing 10% wt/wt soybean oil or a defatted treatment diet containing 10% wt/wt canola oil, and given water containing 1% NaCl. Blood pressure was measured weekly. Blood was collected prior to beginning the diets and at the end of completion of the study for analysis of red blood cell (RBC) antioxidant enzymes, RBC and plasma malondialdehyde (MDA), plasma 8- isoprostane and plasma lipids. Results: Canola oil ingestion significantly decreased the life span of SHRSP rats compared with soybean oil, 85.8 ± 1.1 and 98.3 ± 3.4 days, respectively. Systolic blood pressure increased over time with a significant difference between the diets at the 6th week of feeding. Canola oil ingestion significantly reduced RBC superoxide dismutase, glutathione peroxidase and catalase activities, total cholesterol and low-density lipoprotein cholesterol compared with soybean oil. There were no significant differences in RBC MDA concentration between canola oil fed and soybean oil fed rats. In contrast, plasma MDA and 8-isoprostane concentration was significantly lower in the canola oil group compared to the soybean oil group. Conclusion: In conclusion, canola oil ingestion shortens the life span of SHRSP rats and leads to changes in oxidative status, despite an improvement in the plasma lipids. Notes This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Language eng Field of Research 111103 Nutritional Physiology Socio Economic Objective 920411 Nutrition HERDC Research category C1 Refereed article in a scholarly journal Copyright notice ©2011, BioMed Central Ltd. Persistent URL http://hdl.handle.net/10536/DRO/DU:30042975 Document type: Journal Article Collections: School of Medicine Open Access Collection   Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Tue, 06 Mar 2012, 12:36:04 EST Wed, 07 Mar 2012, 12:48:29 EST Wed, 07 Mar 2012, 12:55:02 EST Wed, 07 Mar 2012, 15:30:17 EST Wed, 07 Mar 2012, 15:38:12 EST Filtered Full Citation counts: Cited 2 times in Scopus Search Google Scholar Access Statistics: 51 Abstract Views, 19 File Downloads  -  Detailed Statistics Created: Tue, 06 Mar 2012, 12:35:53 EST by Jane Moschetti

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.