Serum 25-Hydroxyvitamin D, calcium intake and risk of type 2 diabetes after 5 years : results from a national, population-based prospective study (the Australian Diabetes, Obesity and Lifestyle study)

Gagnon, Claudia, Lu, Zhong X., Magliano, Dianna J., Dunstan, David W., Shaw, Jonathan E., Zimmet, Paul Z., Sikaris, Ken, Grantham, Narelle, Ebeling, Peter R. and Daly, Robin M. 2011, Serum 25-Hydroxyvitamin D, calcium intake and risk of type 2 diabetes after 5 years : results from a national, population-based prospective study (the Australian Diabetes, Obesity and Lifestyle study), Diabetes care, vol. 34, no. 5, pp. 1133-1138.

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Title Serum 25-Hydroxyvitamin D, calcium intake and risk of type 2 diabetes after 5 years : results from a national, population-based prospective study (the Australian Diabetes, Obesity and Lifestyle study)
Author(s) Gagnon, Claudia
Lu, Zhong X.
Magliano, Dianna J.
Dunstan, David W.
Shaw, Jonathan E.
Zimmet, Paul Z.
Sikaris, Ken
Grantham, Narelle
Ebeling, Peter R.
Daly, Robin M.
Journal name Diabetes care
Volume number 34
Issue number 5
Start page 1133
End page 1138
Total pages 6
Publisher American Diabetes Association
Place of publication Alexandria, Va.
Publication date 2011-05
ISSN 0149-5992
1935-5548
Keyword(s) serum 25-hydroxyvitamin D
calcium intake
obesity
non insulin dependent diabetes mellitus
type 2 diabetes
insulin sensitivity
Summary OBJECTIVE To examine whether serum 25-hydroxyvitamin D (25OHD) and dietary calcium predict incident type 2 diabetes and insulin sensitivity.

RESEARCH DESIGN AND METHODS A total of 6,537 of the 11,247 adults evaluated in 1999–2000 in the Australian Diabetes, Obesity and Lifestyle (AusDiab) study, returned for oral glucose tolerance test (OGTT) in 2004–2005. We studied those without diabetes who had complete data at baseline (n = 5,200; mean age 51 years; 55% were women; 92% were Europids). Serum 25OHD and energy-adjusted calcium intake (food frequency questionnaire) were assessed at baseline. Logistic regression was used to evaluate associations between serum 25OHD and dietary calcium on 5-year incidence of diabetes (diagnosed by OGTT) and insulin sensitivity (homeostasis model assessment of insulin sensitivity [HOMA-S]), adjusted for multiple potential confounders, including fasting plasma glucose (FPG).

RESULTS During the 5-year follow-up, 199 incident cases of diabetes were diagnosed. Those who developed diabetes had lower serum 25OHD (mean 58 vs. 65 nmol/L; P < 0.001) and calcium intake (mean 881 vs. 923 mg/day; P = 0.03) compared with those who remained free of diabetes. Each 25 nmol/L increment in serum 25OHD was associated with a 24% reduced risk of diabetes (odds ratio 0.76 [95% CI 0.63–0.92]) after adjusting for age, waist circumference, ethnicity, season, latitude, smoking, physical activity, family history of diabetes, dietary magnesium, hypertension, serum triglycerides, and FPG. Dietary calcium intake was not associated with reduced diabetes risk. Only serum 25OHD was positively and independently associated with HOMA-S at 5 years.

CONCLUSIONS Higher serum 25OHD levels, but not higher dietary calcium, were associated with a significantly reduced risk of diabetes in Australian adult men and women.

Language eng
Field of Research 110399 Clinical Sciences not elsewhere classified
Socio Economic Objective 920104 Diabetes
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2011, American Diabetes Association
Persistent URL http://hdl.handle.net/10536/DRO/DU:30043021

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