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Nicotine dependence in a prospective population-based study of adolescents : the protective role of a functional tyrosine hydroxylase polymorphism

Anney, Richard J. L., Olsson, Craig A., Lotfi-Miri, Mehrnoush, Patton, George C. and Williamson, Robert 2004, Nicotine dependence in a prospective population-based study of adolescents : the protective role of a functional tyrosine hydroxylase polymorphism, Pharmacogenetics, vol. 14, no. 2, pp. 73-81.

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Title Nicotine dependence in a prospective population-based study of adolescents : the protective role of a functional tyrosine hydroxylase polymorphism
Author(s) Anney, Richard J. L.
Olsson, Craig A.ORCID iD for Olsson, Craig A. orcid.org/0000-0002-5927-2014
Lotfi-Miri, Mehrnoush
Patton, George C.
Williamson, Robert
Journal name Pharmacogenetics
Volume number 14
Issue number 2
Start page 73
End page 81
Total pages 9
Publisher Lippincott Williams & Wilkins
Place of publication London, England
Publication date 2004-02
ISSN 0960-314X
Keyword(s) addiction
tobacco use disorder
tyrosine-3-monooxygenase (tyrosine hydroxylase)
longitudinal studies
adolescent
association (genetic)
polymorphism (genetic)
Summary Dopamine is a key neurotransmitter of the mesolimbic reward pathway in the human brain, and tyrosine hydroxylase (TH) is the rate-limiting enzyme in dopamine biosynthesis. Consequently, the gene encoding TH is a strong candidate for involvement in the genetic component of addiction. The importance of this gene in nicotine dependence is supported by many studies showing a link between nicotine administration and TH expression. A functional tetranucleotide repeat polymorphism within intron 1 of the TH gene (HUMTH01-VNTR) has been shown to modify tobacco use in two independent Caucasian samples from the USA and Australia. Using information drawn from an eight-wave Australian population-based longitudinal study of adolescent health, we tested the effect of the HUMTH01-VNTR on nicotine dependence. Comparisons were made between dependent smokers and non-dependent smokers. These data provide further support for a protective association between the K4 allele and dependent smoking (odds ratio 0.54, 95% confidence interval 0.28-1.0). No associations were observed at any of three other common TH polymorphisms (rs6356, rs6357 and HUMTH01-PstI). Including these data, three independent studies, two of which use identical phenotypes, have now identified a protective relationship between the K4 allele of the functional HUMTH01-VNTR polymorphism and high-level smoking.
Language eng
Field of Research 179999 Psychology and Cognitive Sciences not elsewhere classified
Socio Economic Objective 920501 Child Health
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2004, Lippincott Williams & Wilkins
Persistent URL http://hdl.handle.net/10536/DRO/DU:30043810

Document type: Journal Article
Collection: School of Psychology
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