Prospects for epigenetic epidemiology

Foley, Debra L., Craig, Jeffrey M., Morley, Ruth, Olsson, Craig J., Dwyer, Terence, Smith, Katherine and Saffery, Richard 2009, Prospects for epigenetic epidemiology, American journal of epidemiology, vol. 169, no. 4, pp. 389-400, doi: 10.1093/aje/kwn380.

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Title Prospects for epigenetic epidemiology
Alternative title Review : Prospects for epigenetic epidemiology
Author(s) Foley, Debra L.
Craig, Jeffrey M.
Morley, Ruth
Olsson, Craig J.ORCID iD for Olsson, Craig J.
Dwyer, Terence
Smith, Katherine
Saffery, Richard
Journal name American journal of epidemiology
Volume number 169
Issue number 4
Start page 389
End page 400
Total pages 12
Publisher Oxford University Press
Place of publication Cary, NC
Publication date 2009-02-15
ISSN 0002-9262
Keyword(s) DNA methylation
epigenesis, genetic
folic acid
Summary Epigenetic modification can mediate environmental influences on gene expression and can modulate the disease risk associated with genetic variation. Epigenetic analysis therefore holds substantial promise for identifying mechanisms through which genetic and environmental factors jointly contribute to disease risk. The spatial and temporal variance in epigenetic profile is of particular relevance for developmental epidemiology and the study of aging, including the variable age at onset for many common diseases. This review serves as a general introduction to the topic by describing epigenetic mechanisms, with a focus on DNA methylation; genetic and environmental factors that influence DNA methylation; epigenetic influences on development, aging, and disease; and current methodology for measuring epigenetic profile. Methodological considerations for epidemiologic studies that seek to include epigenetic analysis are also discussed.
Language eng
DOI 10.1093/aje/kwn380
Field of Research 179999 Psychology and Cognitive Sciences not elsewhere classified
Socio Economic Objective 920599 Specific Population Health (excl. Indigenous Health) not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2009, The Authors
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Document type: Journal Article
Collection: School of Psychology
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