You are not logged in.

Association between dependent smoking and a polymorphism in the tyrosine hydroxylase gene in a prospective population-based study of adolescent health

Olsson, Craig, Anney, Richard, Forrest, Susan, Patton, George, Coffey, Carolyn, Cameron, Trevor, Hassett, Angela and Williamson, Robert 2004, Association between dependent smoking and a polymorphism in the tyrosine hydroxylase gene in a prospective population-based study of adolescent health, Behavior genetics, vol. 34, no. 1, pp. 85-91, doi: 10.1023/B:BEGE.0000009478.70863.25.

Attached Files
Name Description MIMEType Size Downloads

Title Association between dependent smoking and a polymorphism in the tyrosine hydroxylase gene in a prospective population-based study of adolescent health
Author(s) Olsson, CraigORCID iD for Olsson, Craig orcid.org/0000-0002-5927-2014
Anney, Richard
Forrest, Susan
Patton, George
Coffey, Carolyn
Cameron, Trevor
Hassett, Angela
Williamson, Robert
Journal name Behavior genetics
Volume number 34
Issue number 1
Start page 85
End page 91
Total pages 7
Publisher Springer
Place of publication New York, N. Y.
Publication date 2004
ISSN 0001-8244
Keyword(s) genetics
tyrosine hydroxylase
polymorphism
tobacco dependence
smoking
population sample
longitudinal study
Summary This study reports pilot data on an association between tobacco dependence and a five-allele tetranucleotide repeat polymorphism in the first intron of the tyrosine hydroxylase (TH) gene. One hundred and twenty-six Australian adolescents who had participated in the Health in Transition Study (1993–1997), and who showed patterns of either dependent or nondependent smoking across four waves of data collection, consented to participation in the pilot study. The smoking status of those recruited was confirmed using a telephone-administered drug use questionnaire during 2000. Tobacco dependence was defined as smoking more than 6 days per week and more than 10 cigarettes per day during wave 5 (year 2000) and at lfeast one prior wave (n = 58). A second, more stringent phenotype included smoking within an hour of waking (n = 37). The control group comprised adolescents who had used tobacco but had remained low-level social smokers across each wave of data (n = 56). DNA was collected using a mouthwash procedure. Using the more strictly defined tobacco dependence phenotype, and after adjusting for sex, a significant protective association was found between the K4 allele and tobacco dependence (OR 0.27, 95% confidence interval [CI] 0.09, 0.82). No association was found using the liberal criteria of tobacco dependence (OR 0.51, 95% confidence interval [CI] 0.23, 1.2). These preliminary results replicate a previous association between tobacco use and the K4 allele of the TH gene (Lerman et al., 1997). The potential significance of including time to first cigarette in definitions of tobacco dependence and the possible role that these TH variants might play in tobacco dependence are discussed.
Language eng
DOI 10.1023/B:BEGE.0000009478.70863.25
Field of Research 179999 Psychology and Cognitive Sciences not elsewhere classified
Socio Economic Objective 920501 Child Health
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2004, Plenum Publishing
Persistent URL http://hdl.handle.net/10536/DRO/DU:30043816

Document type: Journal Article
Collection: School of Psychology
Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 22 times in TR Web of Science
Scopus Citation Count Cited 25 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 250 Abstract Views, 0 File Downloads  -  Detailed Statistics
Created: Wed, 21 Mar 2012, 11:54:44 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.