Short-term exercise training early in life restores deficits in pancreatic B-cell mass associated with growth restriction in adult male rats

Laker, Rhianna C., Gallo, Linda A., Wlodek, Mary E., Siebel, Andrew L., Wadley, Glenn D. and McConell, Glenn K. 2011, Short-term exercise training early in life restores deficits in pancreatic B-cell mass associated with growth restriction in adult male rats, AJP : endocrinology and metabolism, vol. 301, no. 5, pp. 931-940.

Attached Files
Name Description MIMEType Size Downloads

Title Short-term exercise training early in life restores deficits in pancreatic B-cell mass associated with growth restriction in adult male rats
Formatted title Short-term exercise training early in life restores deficits in pancreatic ß-cell mass associated with growth restriction in adult male rats
Author(s) Laker, Rhianna C.
Gallo, Linda A.
Wlodek, Mary E.
Siebel, Andrew L.
Wadley, Glenn D.
McConell, Glenn K.
Journal name AJP : endocrinology and metabolism
Volume number 301
Issue number 5
Start page 931
End page 940
Total pages 10
Publisher American Physiological Society
Place of publication Bethesda, Md.
Publication date 2011-11
ISSN 0193-1849
1522-1555
Keyword(s) b-cell
fetal size
insulin secretion
Summary Fetal growth restriction is associated with reduced pancreatic ß-cell mass, contributing to impaired glucose tolerance and diabetes. Exercise training increases ß-cell mass in animals with diabetes and has long-lasting metabolic benefits in rodents and humans. We studied the effect of exercise training on islet and ß-cell morphology and plasma insulin and glucose, following an intraperitoneal glucose tolerance test (IPGTT) in juvenile and adult male Wistar-Kyoto rats born small. Bilateral uterine vessel ligation performed on day 18 of pregnancy resulted in Restricted offspring born small compared with shamoperated Controls and also sham-operated Reduced litter offspring that had their litter size reduced to five pups at birth. Restricted, Control, and Reduced litter offspring remained sedentary or underwent treadmill running from 5 to 9 or 20 to 24 wk of age. Early life exercise increased relative islet surface area and ß-cell mass across all groups at 9 wk, partially restoring the 60–68% deficit (P = 0.05) in Restricted offspring. Remarkably, despite no further exercise training after 9 wk, ß-cell mass was restored in Restricted at 24 wk, while sedentary littermates retained a 45% deficit (P = 0.05) in relative ß-cell mass. Later exercise training also restored Restricted ß-cell mass to Control levels. In conclusion, early life exercise training in rats born small restored ß-cell mass in adulthood and may have beneficial consequences for later metabolic health and disease.
Language eng
Field of Research 111603 Systems Physiology
Socio Economic Objective 920104 Diabetes
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2011, American Physiological Society
Persistent URL http://hdl.handle.net/10536/DRO/DU:30043840

Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 14 times in TR Web of Science
Scopus Citation Count Cited 14 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 55 Abstract Views, 2 File Downloads  -  Detailed Statistics
Created: Thu, 22 Mar 2012, 12:02:44 EST by Jane Moschetti

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.