The role of reducing intakes of saturated fat in the prevention of cardiovascular disease : where does the evidence stand in 2010?

Astrup, Arne, Dyerberg, Jorn, Elwood, Peter, Hermansen, Kjeld, Hu, Frank B., Jakobsen, Marianne Uhre, Kok, Frans J., Krauss, Ronald M., Lecerf, Jean Michel, LeGrand, Philippe, Nestel, Paul, Riserus, Ulf, Sanders, Tom, Sinclair, Andrew, Stender, Steen, Tholstrup, Tine and Willett, Walter C. 2011, The role of reducing intakes of saturated fat in the prevention of cardiovascular disease : where does the evidence stand in 2010?, American journal of clinical nutrition, vol. 93, no. 4, pp. 684-688, doi: 10.3945/aajcn.110.004622.

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Title The role of reducing intakes of saturated fat in the prevention of cardiovascular disease : where does the evidence stand in 2010?
Author(s) Astrup, Arne
Dyerberg, Jorn
Elwood, Peter
Hermansen, Kjeld
Hu, Frank B.
Jakobsen, Marianne Uhre
Kok, Frans J.
Krauss, Ronald M.
Lecerf, Jean Michel
LeGrand, Philippe
Nestel, Paul
Riserus, Ulf
Sanders, Tom
Sinclair, Andrew
Stender, Steen
Tholstrup, Tine
Willett, Walter C.
Journal name American journal of clinical nutrition
Volume number 93
Issue number 4
Start page 684
End page 688
Total pages 5
Publisher American Society for Nutrition
Place of publication Bethesda, Md.
Publication date 2011-04
ISSN 0002-9165
Keyword(s) saturated fatty acids
coronary heart disease
polyunsaturated fatty acids
Summary Current dietary recommendations advise reducing the intake of saturated fatty acids (SFAs) to reduce coronary heart disease (CHD) risk, but recent findings question the role of SFAs. This expert panel reviewed the evidence and reached the following conclusions: the evidence from epidemiologic, clinical, and mechanistic studies is consistent in finding that the risk of CHD is reduced when SFAs are replaced with polyunsaturated fatty acids (PUFAs). In populations who consume a Western diet, the replacement of 1% of energy from SFAs with PUFAs lowers LDL cholesterol and is likely to produce a reduction in CHD incidence of >2–3%. No clear benefit of substituting carbohydrates for SFAs has been shown, although there might be a benefit if the carbohydrate is unrefined and has a low glycemic index. Insufficient evidence exists to judge the effect on CHD risk of replacing SFAs with MUFAs. No clear association between SFA intake relative to refined carbohydrates and the risk of insulin resistance and diabetes has been shown. The effect of diet on a single biomarker is insufficient evidence to assess CHD risk. The combination of multiple biomarkers and the use of clinical endpoints could help substantiate the effects on CHD. Furthermore, the effect of particular foods on CHD cannot be predicted solely by their content of total SFAs because individual SFAs may have different cardiovascular effects and major SFA food sources contain other constituents that could influence CHD risk. Research is needed to clarify the role of SFAs compared with specific forms of carbohydrates in CHD risk and to compare specific foods with appropriate alternatives.
Language eng
DOI 10.3945/aajcn.110.004622
Field of Research 111716 Preventive Medicine
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2011, American Society for Nutrition
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Document type: Journal Article
Collection: School of Medicine
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