Role of nanomedicine in reversing drug resistance mediated by ATP binding cassette transporters and P-glycoprotein in melanoma

Kanwar, Jagat R., Singh, Neha and Kanwar, Rupinder K. 2011, Role of nanomedicine in reversing drug resistance mediated by ATP binding cassette transporters and P-glycoprotein in melanoma, Nanomedicine, vol. 6, no. 4, pp. 701-714.

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Title Role of nanomedicine in reversing drug resistance mediated by ATP binding cassette transporters and P-glycoprotein in melanoma
Author(s) Kanwar, Jagat R.
Singh, Neha
Kanwar, Rupinder K.
Journal name Nanomedicine
Volume number 6
Issue number 4
Start page 701
End page 714
Total pages 14
Publisher Future Medicine
Place of publication London, England
Publication date 2011-06
ISSN 1743-5889
1748-6963
Keyword(s) ATP binding cassette transporter
melanoma
multidrug resistance
nanodelivery
P-glycoprotein
Summary Multidrug resistance (MDR) is one of the most common complex phenomenons exhibited by cancer cells. It is a very common property of melanoma postchemotherapy. MDR transporters, ATP binding cassette (ABC) transporters, play a critical role in conferring this property to melanoma cells. miRNA are post-transcriptional regulators that regulate the expression of these ABC transporters. Targeting these miRNA, in turn targeting ABC transporters with the help of nanodelivery systems to overcome drug resistance, is the primary focus for attaining successful treatment methods for drug-resistant melanoma. These delivery systems are endocytosed by the cancer cells and do not require ABC transporters for their delivery, being a promising therapeutic measure for melanoma.
Language eng
Field of Research 111201 Cancer Cell Biology
Socio Economic Objective 920117 Skin and Related Disorders
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2011, Future Medicine
Persistent URL http://hdl.handle.net/10536/DRO/DU:30044127

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