Targeting hepatitis B virus and human papillomavirus induced carcinogenesis : novel patented therapeutics

Kanwar, Rupinder K., Singh, Neha, Gurudevan, Sneha and Kanwar, Jagat R. 2011, Targeting hepatitis B virus and human papillomavirus induced carcinogenesis : novel patented therapeutics, Recent patents on anti-infective drug discovery, vol. 6, no. 2, pp. 158-174.

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Title Targeting hepatitis B virus and human papillomavirus induced carcinogenesis : novel patented therapeutics
Author(s) Kanwar, Rupinder K.
Singh, Neha
Gurudevan, Sneha
Kanwar, Jagat R.
Journal name Recent patents on anti-infective drug discovery
Volume number 6
Issue number 2
Start page 158
End page 174
Total pages 17
Publisher Bentham Science Publishers
Place of publication Bussum, Netherlands
Publication date 2011-05
ISSN 1574-891X
2212-4071
Keyword(s) cervical cancer
HBV
hepatocellular carcinoma (HCC)
HPV
immunotherapy
SiRNA
survivin
vaccine
Summary Viral infections leading to carcinogenesis tops the risk factors list for the development of human cancer. The decades of research has provided ample scientific evidence that directly links 10-15% of the worldwide incidence of human cancers to the infections with seven human viruses. Moreover, the insights gained into the molecular pathogenetic and immune mechanisms of hepatitis B virus (HBV) and human papillomavirus (HPV) viral transmission to tumour progression, and the identification of their viral surface antigens as well as oncoproteins have provided the scientific community with opportunities to target these virus infections through the development of prophylactic vaccines and antiviral therapeutics. The preventive vaccination programmes targeting HBV and high risk HPV infections, linked to hepatocellular carcinoma (HCC) and cervical cancer respectively have been recently reported to alter age-old cancer patterns on an international scale. In this review, with an emphasis on HBV and HPV mediated carcinogenesis because of the similarities and differences in their global incidence patterns, viral transmission, mortality, molecular pathogenesis and prevention, we focus on the development of recently identified HBV and HPV targeting innovative strategies resulting in several patents and patent applications.
Language eng
Field of Research 111201 Cancer Cell Biology
Socio Economic Objective 920102 Cancer and Related Disorders
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2011, Bentham Science Publishers.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30044135

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