The use of cyclodextrins nanoparticles for oral delivery

Kanwar, J. R., Long, B. M. and Kanwar, R. K. 2011, The use of cyclodextrins nanoparticles for oral delivery, Current medicinal chemistry, vol. 18, no. 14, pp. 2079-2085.

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Title The use of cyclodextrins nanoparticles for oral delivery
Author(s) Kanwar, J. R.
Long, B. M.
Kanwar, R. K.
Journal name Current medicinal chemistry
Volume number 18
Issue number 14
Start page 2079
End page 2085
Total pages 7
Publisher Bentham Science Publishers
Place of publication Hilversum, The Netherlands
Publication date 2011
ISSN 0929-8673
1875-533X
Keyword(s) cyclodextrins and nanoparticles
nanodelivery
oral administration
Summary This review aims to highlight many of the difficulties encountered in trying to achieve the task of delivering proteins and peptides through oral administration. The necessity of controlled protein and peptide release, protection and stability in the gastrointestinal tract, and ability to target specific areas are only a handful of the many problems associated with trying to engineer a useful solution. Current research gives strong indication that both cyclodextrins and nanoparticles could be highly useful in the search for a suitable method for such successful oral delivery of proteins and peptides. This review focuses on the use of cyclodextrins in pharmaceuticals, aiming to discuss the use of cyclodextrins in conjunction with nanoparticles for oral delivery of proteins. Both classical applications and more advanced "nanomedical" approaches are discussed. In order to achieve a complete overview this review will include background information about cyclodextrins, nanomedicine and their role in oral delivery systems. The use of absorption enhancers like cyclodextrins, bile salts and surfactants was used to facilitate bio-availability into the system. The state-of-the-art technology and challenges in this area are discussed, with typical examples.
Language eng
Field of Research 111502 Clinical Pharmacology and Therapeutics
Socio Economic Objective 920199 Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2011, Bentham Science Publishers
Persistent URL http://hdl.handle.net/10536/DRO/DU:30044152

Document type: Journal Article
Collection: Centre for Biotechnology and Interdisciplinary Sciences (BioDeakin)
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