Structural characterisation and bioactivities of hybrid carrageenan-like sulphated galactan from red alga Furcellaria lumbricalis

Yang, Bo, Yu, Guangli, Zhao, Xia, Ren, Weina, Jiao, Guangling, Fang, Lianhua, Wang, Yuehua, Du, Guanhua, Tiller, Christa, Girouard, Gabrielle, Barrow, Colin J., Ewart, H. Stephen and Zhang, Junzeng 2011, Structural characterisation and bioactivities of hybrid carrageenan-like sulphated galactan from red alga Furcellaria lumbricalis, Food chemistry, vol. 124, no. 1, pp. 50-57.

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Title Structural characterisation and bioactivities of hybrid carrageenan-like sulphated galactan from red alga Furcellaria lumbricalis
Formatted title Structural characterisation and bioactivities of hybrid carrageenan-like sulphated galactan from red alga Furcellaria lumbricalis
Author(s) Yang, Bo
Yu, Guangli
Zhao, Xia
Ren, Weina
Jiao, Guangling
Fang, Lianhua
Wang, Yuehua
Du, Guanhua
Tiller, Christa
Girouard, Gabrielle
Barrow, Colin J.
Ewart, H. Stephen
Zhang, Junzeng
Journal name Food chemistry
Volume number 124
Issue number 1
Start page 50
End page 57
Total pages 8
Publisher Elsevier BV
Place of publication Amsterdam, The Netherlands
Publication date 2011-01-01
ISSN 0308-8146
1873-7072
Keyword(s) bioactivities
depolymerisation
Furcellaria lumbricalis
purification
sulphated galactan
Summary The red alga, Furcellaria lumbricalis from the coast of the Prince Edward Island (PEI) in Atlantic Canada, was extracted with hot water and fractionated with 0.125. M KCl to obtain a carrageenan-like polysaccharide. The polysaccharide was further purified on ion-exchange and gel-permeation chromatography to yield a fraction (FB1) of uniform size and charge, with an average molecular weight of 428. kD. Oligosaccharides generated with acid hydrolysis of FB1 were sequenced using the electrospray ionisation collision induced dissociation tandem mass spectrometry (ES-CID-MS/MS) technique. On the basis of chemical and spectroscopic analysis, FB1 was characterised to be composed of 1,4-linked 3,6-anhydro-galactose (40%), 1,3-linked 4-sulphated-galactose (30%), 1,3-linked galactose (20%), 1,4-linked galactose (8%) and 1,4-linked 3-O-methyl-galactose (2%), which makes it be a novel sulphated galactan hybrid. The β-secretase (BACE) inhibition and immunomodulation activities of FB1-derived oligosaccharides were evaluated in vitro.
Language eng
Field of Research 090802 Food Engineering
Socio Economic Objective 860105 Nutraceuticals and Functional Foods
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2010, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30044275

Document type: Journal Article
Collection: School of Life and Environmental Sciences
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