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Development of ligand incorporated chitosan nanoparticles for the selective delivery of 5-fluorouracil to colon

Li, Puwang, Peng, Zheng, She, F. H. and Kong, L. X. 2011, Development of ligand incorporated chitosan nanoparticles for the selective delivery of 5-fluorouracil to colon, Advanced materials research, vol. 197-198, pp. 238-241.

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Title Development of ligand incorporated chitosan nanoparticles for the selective delivery of 5-fluorouracil to colon
Author(s) Li, Puwang
Peng, Zheng
She, F. H.
Kong, L. X.
Journal name Advanced materials research
Volume number 197-198
Start page 238
End page 241
Total pages 4
Publisher Trans Tech Publications
Place of publication Stafa-Zurich, Switzerland
Publication date 2011
ISSN 1022-6680
Keyword(s) chitosan
drug delivery systems
folate
nanoparticles
Summary Drug delivery systems with active targeting ligand provide improved therapeutic efficiency due to the selectivity towards tumor cells. In this paper we prepared drug loaded nanoparticles (NPs) using folate (FA) incorporated chitosan (FA-CS) based on ionic gelation technology. FA-CS NPs were spherical in shape with an average particle size of 100 nm, while 5-fluorouracil (5-FU) loaded NPs became less circular with average particle size of 100-500 nm. NPs made from FA-CS conjugates exhibited improved capability to encapsulate hydrophilic 5-FU. It was found 5-FU distributed in FA-CS NPs in solid solution state. In vitro release results demonstrated the release of 5-FU from FA-CS NPs was more controllable as compared to that of CS NPs.
Language eng
Field of Research 090301 Biomaterials
Socio Economic Objective 920102 Cancer and Related Disorders
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2011, Trans Tech Publications, Switzerland
Persistent URL http://hdl.handle.net/10536/DRO/DU:30044336

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